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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 19 — Sep. 14, 2009
  • pp: 17016–17033

Late-fluorescence mammography assesses tumor capillary permeability and differentiates malignant from benign lesions

Axel Hagen, Dirk Grosenick, Rainer Macdonald, Herbert Rinneberg, Susen Burock, Peter Warnick, Alexander Poellinger, and Peter M. Schlag  »View Author Affiliations


Optics Express, Vol. 17, Issue 19, pp. 17016-17033 (2009)
http://dx.doi.org/10.1364/OE.17.017016


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Abstract

Using scanning time-domain instrumentation we recorded fluorescence projection mammograms on few breast cancer patients prior, during and after infusion of indocyanine green (ICG), while monitoring arterial ICG concentration by transcutaneous pulse densitometry. Late-fluorescence mammograms recorded after ICG had been largely cleared from the blood by the liver, showed invasive carcinomas at high contrast over a rather homogeneous background, whereas benign lesions did not produce (focused) fluorescence contrast. During infusion, tissue concentration contrast and hence fluorescence contrast is determined by intravascular contributions, whereas late-fluorescence mammograms are dominated by contributions from protein-bound ICG extravasated into the interstitium, reflecting relative microvascular permeabilities of carcinomas and normal breast tissue. We simulated intravascular and extravascular contributions to ICG tissue concentration contrast within a two-compartment unidirectional pharmacokinetic model.

© 2009 OSA

OCIS Codes
(170.3830) Medical optics and biotechnology : Mammography
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(260.2510) Physical optics : Fluorescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 8, 2009
Revised Manuscript: August 20, 2009
Manuscript Accepted: August 24, 2009
Published: September 9, 2009

Virtual Issues
Vol. 4, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Axel Hagen, Dirk Grosenick, Rainer Macdonald, Herbert Rinneberg, Susen Burock, Peter Warnick, Alexander Poellinger, and Peter M. Schlag, "Late-fluorescence mammography assesses tumor capillary permeability and differentiates malignant from benign lesions," Opt. Express 17, 17016-17033 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-19-17016


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