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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 2 — Jan. 19, 2009
  • pp: 509–519

Skin autofluorescence for the risk assessment of chronic complications in diabetes: a broad excitation range is sufficient

M. Koetsier, H. L. Lutgers, A. J. Smit, T. P. Links, R. de Vries, R. O. B. Gans, G. Rakhorst, and R. Graaff  »View Author Affiliations


Optics Express, Vol. 17, Issue 2, pp. 509-519 (2009)
http://dx.doi.org/10.1364/OE.17.000509


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Abstract

Skin autofluorescence (AF) is becoming an accepted clinical method for assessing the risk of chronic complications in diabetes mellitus (DM). In this study, the role of the excitation wavelength in the recognition of increased risk of diabetes-related chronic complications was investigated. An Excitation Emission Matrix Scanner (EEMS) was used to perform non-invasive measurements in four age-matched groups of patients with type 1 and type 2 DM, with and without chronic complications, as well as in a control group (N=97 in total). AF was calculated for excitation wavelengths in the range 355 – 405 nm. Mean spectra were assessed per group.AF values in both type 1 and type 2 DM patients with complications were increased compared to the control subjects (p < 0.01); this ratio remained practically constant, independent of the excitation wavelength. No emission peaks were distinctive for specific patient groups.We conclude that in these groups, no characteristic fluorophores dictate the use of a specific wavelength or set of wavelengths. The results show the validity of applying a broad excitation wavelength range for risk assessment of chronic complications in diabetes.

© 2009 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6280) Spectroscopy : Spectroscopy, fluorescence and luminescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 18, 2008
Revised Manuscript: November 25, 2008
Manuscript Accepted: December 17, 2008
Published: January 7, 2009

Virtual Issues
Vol. 4, Iss. 3 Virtual Journal for Biomedical Optics

Citation
M. Koetsier, H. Lutgers, A. J. Smit, T. P. Links, R. d. Vries, R. O. Gans, G. Rakhorst, and R. Graaff, "Skin autofluorescence for the risk assessment of chronic complications in diabetes: a broad excitation range is sufficient," Opt. Express 17, 509-519 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-2-509


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