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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 20 — Sep. 28, 2009
  • pp: 17426–17440

Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography

Arata Miyazawa, Masahiro Yamanari, Shuichi Makita, Masahiro Miura, Keisuke Kawana, Keiichi Iwaya, Hiroshi Goto, and Yoshiaki Yasuno  »View Author Affiliations


Optics Express, Vol. 17, Issue 20, pp. 17426-17440 (2009)
http://dx.doi.org/10.1364/OE.17.017426


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Abstract

We developed a tissue discrimination algorithm of polarization sensitive optical coherence tomography (PS-OCT) based on the optical properties of tissues. We calculated the three-dimensional (3D) feature vector from the parameters intensity, extinction coefficient, birefringence, which were obtained by PS-OCT. The tissue type of each pixel was determined according to the position of the feature vector in the 3D feature space. The algorithm was applied for discriminating tissues of the human anterior eye segment. The conjunctiva, sclera, trabecular meshwork (TM), cornea, and uvea were well separated in the 3D feature space, and we observed them with good contrast. The TM line can be observed in the 3D discriminated volume, as observed by gonioscopy. We validated our method by applying our algorithm and histological data to porcine eyes. A marker was injected into sub-Tenon’s space and the tissues that were anterior to the marker and posterior to the marker were successfully segmented by our algorithm.

© 2009 Optical Society of America

OCIS Codes
(100.5010) Image processing : Pattern recognition
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(230.5440) Optical devices : Polarization-selective devices

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 3, 2009
Revised Manuscript: September 1, 2009
Manuscript Accepted: September 5, 2009
Published: September 15, 2009

Virtual Issues
Vol. 4, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Arata Miyazawa, Masahiro Yamanari, Shuichi Makita, Masahiro Miura, Keisuke Kawana, Keiichi Iwaya, Hiroshi Goto, and Yoshiaki Yasuno, "Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography," Opt. Express 17, 17426-17440 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-20-17426


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