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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 24 — Nov. 23, 2009
  • pp: 21376–21395

Analysis of fast full angle fluorescence diffuse optical tomography with beam-forming illumination

Daifa Wang, Xin Liu, and Jing Bai  »View Author Affiliations


Optics Express, Vol. 17, Issue 24, pp. 21376-21395 (2009)
http://dx.doi.org/10.1364/OE.17.021376


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Abstract

Challenges remain in imaging fast biological activities through whole body using fluorescence diffuse optical tomography (FDOT). We propose and analyze three full angle FDOT systems with different beam-forming illuminations (BF-FDOT), including line illumination (L-FDOT), area illumination (A-FDOT), and multiple-points illumination (MP-FDOT). Singular value analysis and experimental validation are used to optimize the experimental parameters in terms of hardware design, data collection and utilization. Comparisons are made on the system performance between L-FDOT and the conventional point illumination based full angle FDOT system (P-FDOT) with both numerical simulation and phantom experiment. We demonstrate that at least three cycles of projections are needed for P-FDOT to achieve comparable whole body image quality with L-FDOT. We also compare these three BF-FDOT systems and further discuss how these optimized parameters can be employed to improve spatial and temporal performances within current computational capacities, and guide the design of the BF-FDOT systems.

© 2009 OSA

OCIS Codes
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 2, 2009
Revised Manuscript: September 27, 2009
Manuscript Accepted: October 21, 2009
Published: November 9, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Daifa Wang, Xin Liu, and Jing Bai, "Analysis of fast full angle fluorescence diffuse optical tomography with beam-forming illumination," Opt. Express 17, 21376-21395 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-24-21376


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