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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 24 — Nov. 23, 2009
  • pp: 21414–21426

Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging

Rui Ma, Adrian Taruttis, Vasilis Ntziachristos, and Daniel Razansky  »View Author Affiliations


Optics Express, Vol. 17, Issue 24, pp. 21414-21426 (2009)
http://dx.doi.org/10.1364/OE.17.021414


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Abstract

A major difficulty arising from whole-body optoacoustic imaging is the long acquisition times associated with recording signals from multiple spatial projections. The acquired signals are also generally weak and the signal-to-noise-ratio is low, problems often solved by signal averaging, which complicates acquisition and increases acquisition times to an extent that makes many in vivo applications challenging or even impossible. Herein we present a fast acquisition multispectral optoacoustic tomography (MSOT) scanner for whole-body visualization of molecular markers in small animals. Multi-wavelength illumination offers the possibility to resolve exogenously administered fluorescent probes, biomarkers, and other intrinsic and exogenous chromophores. The system performance is determined in phantom experiments involving molecular probes and validated by imaging of small animals of various scales.

© 2009 OSA

OCIS Codes
(110.6880) Imaging systems : Three-dimensional image acquisition
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 28, 2009
Revised Manuscript: October 23, 2009
Manuscript Accepted: October 27, 2009
Published: November 9, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Rui Ma, Adrian Taruttis, Vasilis Ntziachristos, and Daniel Razansky, "Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging," Opt. Express 17, 21414-21426 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-24-21414


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