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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 24 — Nov. 23, 2009
  • pp: 21925–21934

Adaptive improved element free Galerkin method for quasi- or multi-spectral bioluminescence tomography

Chenghu Qin, Xin Yang, Jinchao Feng, Kai Liu, Junting Liu, Guorui Yan, Shouping Zhu, Min Xu, and Jie Tian  »View Author Affiliations


Optics Express, Vol. 17, Issue 24, pp. 21925-21934 (2009)
http://dx.doi.org/10.1364/OE.17.021925


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Abstract

Bioluminescence tomography (BLT) has become a powerful tool for whole-body small animal imaging. In this contribution, an adaptive improved element free Galerkin method (IEFGM) is presented to perform a quantitative reconstruction of the internal light source using quasi- or multi-spectral information, which not only can avoid the time-consuming mesh generation but also can reduce the ill-posedness of BLT effectively. In the algorithm, the reconstruction can be largely enhanced by an adaptive technology based on a posteriori error estimation. Finally, the numerical and physical phantom experiment results show that the bioluminescent source can be recovered accurately.

© 2009 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 10, 2009
Revised Manuscript: October 29, 2009
Manuscript Accepted: November 6, 2009
Published: November 16, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Chenghu Qin, Jie Tian, Xin Yang, Jinchao Feng, Kai Liu, Junting Liu, Guorui Yan, Shouping Zhu, and Min Xu, "Adaptive improved element free Galerkin method for quasi- or multi-spectral bioluminescence tomography," Opt. Express 17, 21925-21934 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-24-21925


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