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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 24 — Nov. 23, 2009
  • pp: 22041–22046

Combined photoacoustic and ultrasound biomicroscopy

Tyler Harrison, Janaka C. Ranasinghesagara, Huihong Lu, Kory Mathewson, Andrew Walsh, and Roger J. Zemp  »View Author Affiliations

Optics Express, Vol. 17, Issue 24, pp. 22041-22046 (2009)

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We report on the development of an imaging system capable of combined ultrasound and photoacoustic imaging based on a fast-scanning single-element 25-MHz ultrasound transducer and a unique light-delivery system. The system is capable of 20 ultrasound frames per second and slower photoacoustic frame rates limited by laser pulse-repetition rates. Laser and ultrasound pulses are interlaced for co-registration of photoacoustic and ultrasound images. In vivo imaging of a human finger permits ultrasonic visualization of vessel structures and speckle changes indicative of blood flow, while overlaid photoacoustic images highlight some small vessels that are not clear from the ultrasound scan. Photoacoustic images provide optical absorption contrast co-registered in the structural and blood-flow context of ultrasound with high-spatial resolution and may prove important for clinical diagnostics and basic science of the microvasculature.

© 2009 OSA

OCIS Codes
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.7170) Medical optics and biotechnology : Ultrasound

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 16, 2009
Revised Manuscript: November 10, 2009
Manuscript Accepted: November 12, 2009
Published: November 17, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Tyler Harrison, Janaka C. Ranasinghesagara, Huihong Lu, Kory Mathewson, Andrew Walsh, and Roger J. Zemp, "Combined photoacoustic and ultrasound biomicroscopy," Opt. Express 17, 22041-22046 (2009)

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