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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 24 — Nov. 23, 2009
  • pp: 22190–22200

Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique

Jeff Fingler, Robert J. Zawadzki, John S. Werner, Dan Schwartz, and Scott E. Fraser  »View Author Affiliations


Optics Express, Vol. 17, Issue 24, pp. 22190-22200 (2009)
http://dx.doi.org/10.1364/OE.17.022190


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Abstract

Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina. This contrast technique spatially identifies locations of motion within the retina primarily associated with vasculature. Histogram-based noise analysis of the motion contrast images was used to reduce the motion noise created by transverse eye motion. En face summation images created from the 3D motion contrast data are presented with segmentation of selected retinal layers to provide non-invasive vascular visualization comparable to currently used invasive angiographic imaging. This motion contrast technique has demonstrated the ability to visualize resolution-limited vasculature independent of vessel orientation and flow velocity.

© 2009 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 27, 2009
Revised Manuscript: October 6, 2009
Manuscript Accepted: November 6, 2009
Published: November 19, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Jeff Fingler, Robert J. Zawadzki, John S. Werner, Dan Schwartz, and Scott E. Fraser, "Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique," Opt. Express 17, 22190-22200 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-24-22190


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