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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 3 — Feb. 2, 2009
  • pp: 1600–1609

Mueller decomposition images for cervical tissue: Potential for discriminating normal and dysplastic states

Prashant Shukla and Asima Pradhan  »View Author Affiliations

Optics Express, Vol. 17, Issue 3, pp. 1600-1609 (2009)

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We report the potential of Mueller decomposition images to discriminate the normal against the dysplastic (precancerous) states in cervical tissue. It is observed that in the epithelium region, depolarization power is sensitive to morphological changes during progression from normal to dysplastic state while retardance and diattenuation do not show any significant change. These morphological changes have been correlated with the microscopic images of the tissues. In contrast, it is the retardance which reveals the morphological changes around the stromal region. Additionally, we have evaluated the arithmetic mean of depolarization power and retardance from their respective decomposed images and have shown that this parameter has a potential to discriminate normal tissues against dysplastic ones.

© 2009 Optical Society of America

OCIS Codes
(170.6930) Medical optics and biotechnology : Tissue
(290.0290) Scattering : Scattering
(290.7050) Scattering : Turbid media
(110.0113) Imaging systems : Imaging through turbid media
(290.5855) Scattering : Scattering, polarization

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 21, 2008
Revised Manuscript: January 16, 2009
Manuscript Accepted: January 22, 2009
Published: January 27, 2009

Virtual Issues
Vol. 4, Iss. 4 Virtual Journal for Biomedical Optics

Prashant Shukla and Asima Pradhan, "Mueller decomposition images for cervical tissue: Potential for discriminating normal and dysplastic states," Opt. Express 17, 1600-1609 (2009)

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