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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 4 — Feb. 16, 2009
  • pp: 2780–2796

Optics InfoBase > Optics Express > Volume 17 > Issue 4 > Page 2780

Compact beveled fiber optic probe design for enhanced depth discrimination in epithelial tissues

Linda T. Nieman, Marko Jakovljevic, and Konstantin Sokolov  »View Author Affiliations


Optics Express, Vol. 17, Issue 4, pp. 2780-2796 (2009)
http://dx.doi.org/10.1364/OE.17.002780


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Abstract

We report the development and evaluation of a simple compact probe that incorporates multiple beveled fibers for depth sensitive detection of spectroscopic signals in vivo. We evaluated three probes with bevel angles 35, 40, and 45 degrees for their collection efficiency and depth resolution using a thin highly scattering white substrate and found that a 40 degree bevel provides the best characteristics for depth-resolved spectroscopy. The depth sensitivity of the probe with 40 degree beveled fibers was then evaluated using multilayer phantoms with scattering properties mimicking precancerous tissue and in vivo on normal human oral mucosa. The results demonstrate that the use of multiple beveled fibers has the capability to simultaneously collect scattering spectra from a range of depths within epithelial tissue that has the potential to provide further significant improvement of detection and monitoring of epithelial precancers.

© 2009 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.0290) Scattering : Scattering
(300.0300) Spectroscopy : Spectroscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 5, 2008
Revised Manuscript: January 30, 2009
Manuscript Accepted: February 1, 2009
Published: February 11, 2009

Virtual Issues
Vol. 4, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Linda T. Nieman, Marko Jakovljevic, and Konstantin Sokolov, "Compact beveled fiber optic probe design for enhanced depth discrimination in epithelial tissues," Opt. Express 17, 2780-2796 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-4-2780


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