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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 5 — Mar. 2, 2009
  • pp: 3469–3475

Nanoparticle-enabled terahertz imaging for cancer diagnosis

Seung Jae Oh, Jinyoung Kang, Inhee Maeng, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam, and Joo -Hiuk Son  »View Author Affiliations

Optics Express, Vol. 17, Issue 5, pp. 3469-3475 (2009)

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This paper demonstrates the principle of the nanoparticle-contrast-agent-enabled terahertz imaging (CATHI) technique, which yields a dramatic sensitivity of the differential signal from cancer cells with nanoparticles. The terahertz (THz) reflection signal increased beam by 20% in the cancer cells with nanoparticles of gold nano-rods (GNRs) upon their irradiation with a infrared (IR) laser, due to the temperature rise of water in cancer cells by surface plasma ploritons. In the differential mode, the THz signal from the cancer cells with GNRs was 30 times higher than that from the cancer cells without GNRs. As the high sensitivity is achieved by the surface plasmon resonance through IR laser irradiation, the resolution of the CATHI technique can be as good as a few microns and THz endoscopy becomes more feasible.

© 2009 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6795) Medical optics and biotechnology : Terahertz imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 6, 2009
Revised Manuscript: February 15, 2009
Manuscript Accepted: February 16, 2009
Published: February 20, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics

Seung Jae Oh, Jinyoung Kang, Inhee Maeng, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam, and Joo-Hiuk Son, "Nanoparticle-enabled terahertz imaging for cancer diagnosis," Opt. Express 17, 3469-3475 (2009)

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