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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 5 — Mar. 2, 2009
  • pp: 3884–3902

Transcranial Optical Monitoring of Cerebrovascular Hemodynamics in Acute Stroke Patients

Turgut Durduran, Chao Zhou, Brian L Edlow, Guoqiang Yu, Regine Choe, Meeri N Kim, Brett L Cucchiara, Mary E Putt, Qaisar Shah, Scott E Kasner, Joel H Greenberg, Arjun G Yodh, and John A Detre  »View Author Affiliations


Optics Express, Vol. 17, Issue 5, pp. 3884-3902 (2009)
http://dx.doi.org/10.1364/OE.17.003884


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Abstract

“Diffuse correlation spectroscopy” (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with “near-infrared spectroscopy” (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, -5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (HbO2) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

© 2009 Optical Society of America

OCIS Codes
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 24, 2008
Revised Manuscript: January 22, 2009
Manuscript Accepted: January 25, 2009
Published: February 27, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Turgut Durduran, Chao Zhou, Brian L. Edlow, Guoqiang Yu, Regine Choe, Meeri N. Kim, Brett L. Cucchiara, Mary E. Putt, Qaisar Shah, Scott E. Kasner, Joel H. Greenberg, Arjun G. Yodh, and John A. Detre, "Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients," Opt. Express 17, 3884-3902 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-5-3884


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