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Three-dimensional polarization sensitive OCT imaging and interactive display of the human retina
Erich Götzinger, Michael Pircher, Bernhard Baumann, Christian Ahlers, Wolfgang Geitzenauer, Ursula Schmidt-Erfurth, and Christoph K. Hitzenberger »View Author Affiliations
1Center for Biomedical Engineering and Physics, Medical University of Vienna, Austria
2Department of Ophthalmology, General Hospital and Medical University of Vienna, Austria
*Corresponding author: christoph.hitzenberger@meduniwien.ac.at
Optics Express, Vol. 17, Issue 5, pp. 4151-4165 (2009)
http://dx.doi.org/10.1364/OE.17.004151
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Abstract
Polarization sensitive OCT has recently been shown to provide tissue specific contrast, enabling direct identification of retinal layers based on the intrinsic properties of their interaction with light. However, the capabilities of displaying and analyzing 3D datasets in scientific publications were rather limited. Within the framework of the Interactive Science Publishing project, we present new ways of displaying and analyzing 3D sets of various polarization parameters recorded in healthy and diseased human retinas. These datasets can be interactively explored by the reader. Furthermore, we provide data of the 3D distribution of backscattered Stokes vectors to allow the reader to develop and test their own data processing algorithms.
© 2009 Optical Society of America
OCIS Codes
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(230.5440) Optical devices : Polarization-selective devices
ToC Category:
Functional OCT
History
Original Manuscript: October 30, 2008
Revised Manuscript: January 15, 2009
Manuscript Accepted: January 22, 2009
Published: March 2, 2009
Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics
Interactive Science Publishing Focus Issue: Optical Coherence Tomography (OCT) (2009) Optics Express
Citation
Erich Götzinger, Michael Pircher, Bernhard Baumann, Christian Ahlers, Wolfgang Geitzenauer, Ursula Schmidt-Erfurth, and Christoph K. Hitzenberger, "Three-dimensional polarization sensitive OCT imaging and interactive display of the human retina," Opt. Express 17, 4151-4165 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-5-4151
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References
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- U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46, 3393-3402 (2005). [CrossRef] [PubMed]
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- M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005). [CrossRef] [PubMed]
- M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, "Imaging polarimetry in age-related macular degeneration," Invest. Ophthalmol. Vis. Sci. 49, 2661-2667 (2008). [CrossRef] [PubMed]
- A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995). [CrossRef]
- U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46, 3393-3402 (2005). [CrossRef] [PubMed]
- A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, "Optical coherence tomography - principles and applications," Rep. Prog. Phys. 66, 239-303 (2003). [CrossRef]
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- M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002). [CrossRef] [PubMed]
- C. K. Hitzenberger, E. Götzinger, M. Sticker, M. Pircher, and A. F. Fercher, "Measurement and imaging of birefringence and optic axis orientation by phase resolved polarization sensitive optical coherence tomography," Opt. Express 9, 780-790 (2001). http://www.opticsexpress.org/abstract.cfm?URI=OPEX-9-13-780. [CrossRef] [PubMed]
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