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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 5 — Mar. 2, 2009
  • pp: 4221–4235

Ultrahigh-resolution versus speckle noise-reduction in spectral-domain optical coherence tomography

Masanori Hangai, Motoshi Yamamoto, Atsushi Sakamoto, and Nagahisa Yoshimura  »View Author Affiliations


Optics Express, Vol. 17, Issue 5, pp. 4221-4235 (2009)
http://dx.doi.org/10.1364/OE.17.004221


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Abstract

Ultrahigh-resolution (UHR) spectral-domain optical coherence tomography (SD-OCT) and speckle noise-reduced SD-OCT instruments were compared with regard to their ability to visualize retinal microstructures and detect micropathologies in the same series of eyes in this hospital-based study. Both the instruments identically visualized normal retinal structures, except for the retinal ganglion cell layer, which was better delineated by the speckle noise-reduced SD-OCT instrument. Retinal pigment epithelium (RPE) and Bruch’s membrane were better delineated by UHR SD-OCT. Retinal and sub-RPE pathologies were also identically visualized by both the instruments. Layer differentiation for locating each pathology was better visualized by speckle noise-reduced SD-OCT.

© 2009 Optical Society of America

OCIS Codes
(110.4280) Imaging systems : Noise in imaging systems
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Visualization and Image Processing in OCT

History
Original Manuscript: October 3, 2008
Revised Manuscript: January 25, 2009
Manuscript Accepted: February 27, 2009
Published: March 2, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics
Interactive Science Publishing Focus Issue: Optical Coherence Tomography (OCT) (2009) Optics Express

Citation
Masanori Hangai, Motoshi Yamamoto, Atsushi Sakamoto, and Nagahisa Yoshimura, "Ultrahigh-resolution versus speckle noise-reduction in spectral-domain optical coherence tomography," Opt. Express 17, 4221-4235 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-5-4221


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References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991). [CrossRef] [PubMed]
  2. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-894 (2003). [CrossRef] [PubMed]
  3. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Signal to noise gain of spectral domain over time domain optical coherence tomography," Opt. Lett. 28,2067-2069 (2003). [CrossRef] [PubMed]
  4. M. A. Choma, M. V. Sarunic, C. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and fourier domain optical coherence tomography," Opt. Express 11,2183-2189 (2003). [CrossRef] [PubMed]
  5. N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In-vivo human retinal imaging by ultra high-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-482 (2004). [CrossRef] [PubMed]
  6. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by fourier domain optical coherence tomography," J. Biomed. Opt. 7,457-463 (2002). [CrossRef] [PubMed]
  7. M. Wojtkowski, T. Bajraszewski, P. Targowski, and A. Kowalczyk, "Real-time in vivo imaging by high-speed spectral optical coherence tomography," Opt. Lett. 28,1745-1747 (2003). [CrossRef] [PubMed]
  8. W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001). [CrossRef] [PubMed]
  9. W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003). [CrossRef] [PubMed]
  10. T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004). [CrossRef] [PubMed]
  11. E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005). [CrossRef]
  12. T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005). [CrossRef]
  13. M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005). [CrossRef] [PubMed]
  14. A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006). [CrossRef] [PubMed]
  15. L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006). [CrossRef] [PubMed]
  16. T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006). [CrossRef] [PubMed]
  17. U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005). [CrossRef] [PubMed]
  18. M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. Kowalczyk, J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005). [CrossRef] [PubMed]
  19. V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology  113,2054-2065.e3 (2006). [CrossRef] [PubMed]
  20. T.H. Ko, D.C. Adler, JG. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Optics Express 12,2112-2119 (2004). [CrossRef] [PubMed]
  21. T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005). [CrossRef] [PubMed]
  22. B. Sander, M. Larsen, L. Thrane L, J. L. Hougaard, and T. M. Jorgensen, "Enhanced optical coherence tomography imaging by multiple scan averaging," Br. J. Ophthalmol. 89, 207-212 (2005). [CrossRef] [PubMed]
  23. A. Sakamoto, M. Hangai, and N. Yoshimura, "Spectral-domain optical coherence tomography with multiple B-scan averaging for enhanced imaging of retinal diseases," Ophthalmology 115,1071-1078.e7 (2008). [CrossRef]
  24. V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008). [CrossRef] [PubMed]
  25. Y. Ojima, M. Hangai, A. Sakamoto, A. Tsujikawa, A. Otani, H. Tamura, and N. Yoshimura, "Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography," Retina 29,52-59 (2009). [CrossRef]

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