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Optics Express

Optics Express

  • Vol. 17, Iss. 7 — Mar. 30, 2009
  • pp: 5867–5878

Fluorescence enhancements of fiber-optic biosensor with metallic nanoparticles

Ming-Yaw Ng and Wei-Chih Liu  »View Author Affiliations


Optics Express, Vol. 17, Issue 7, pp. 5867-5878 (2009)
http://dx.doi.org/10.1364/OE.17.005867


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Abstract

The mechanism of fluorescence enhancements of fiber-optic biosensor with metallic nanoparticles is studied using scattering theory of evanescent waves by a metallic nanoparticle in dilute solution approximation. High local-field enhancement in the vicinity of metallic nanoparticles resulting from localized surface plasmon excitation and the fluorescence enhancement is estimated by calculating averaged local-field enhancement and radiative-rate enhancement of fluorophores in the presence of metallic nanoparticles. The metallic nanoparticles not only provide strong local field to enhance the fluorescence signal of fluorophores, but also help to scatter the fluorescence signal and to increase the far-field detectable signals of the fiber-optic biosensor. The effects of the radius of gold nanoparticles, fluorophore-particle separation, and fiber-particle separation on the fluorescence enhancement are discussed in detail.

© 2009 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(240.6680) Optics at surfaces : Surface plasmons

ToC Category:
Optics at Surfaces

History
Original Manuscript: February 12, 2009
Manuscript Accepted: March 22, 2009
Published: March 26, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Ming-Yaw Ng and Wei-Chih Liu, "Fluorescence enhancements of fiber-optic biosensor with metallic nanoparticles," Opt. Express 17, 5867-5878 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-7-5867


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