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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 10 — May. 10, 2010
  • pp: 10462–10472

Dynamic deformation of red blood cell in Dual-trap Optical Tweezers

Sebastien Rancourt-Grenier, Ming-Tzo Wei, Jar-Jin Bai, Arthur Chiou, Paul P. Bareil, Pierre-Luc Duval, and Yunlong Sheng  »View Author Affiliations


Optics Express, Vol. 18, Issue 10, pp. 10462-10472 (2010)
http://dx.doi.org/10.1364/OE.18.010462


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Abstract

Three-dimensional dynamic deformation of a red blood cell in a dual-trap optical tweezers is computed with the elastic membrane theory and is compared with the experimental results. When a soft particle is trapped by a laser beam, the particle is deformed depending on the radiation stress distribution whereas the stress distribution on the particle in turn depends on the deformation of its morphological shape. We compute the stress re-distribution on the deformed cell and its subsequent deformations recursively until a final equilibrium state solution is achieved. The experiment is done with the red blood cells in suspension swollen to spherical shape. The cell membrane elasticity coefficient is obtained by fitting the theoretical prediction with the experimental data. This approach allows us to evaluate up to 20% deformation of cell’s shape

© 2010 OSA

OCIS Codes
(140.7010) Lasers and laser optics : Laser trapping
(170.1530) Medical optics and biotechnology : Cell analysis
(170.4520) Medical optics and biotechnology : Optical confinement and manipulation
(350.4855) Other areas of optics : Optical tweezers or optical manipulation

ToC Category:
Optical Trapping and Manipulation

History
Original Manuscript: February 11, 2010
Revised Manuscript: March 18, 2010
Manuscript Accepted: April 22, 2010
Published: May 5, 2010

Virtual Issues
Vol. 5, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Sebastien Rancourt-Grenier, Ming-Tzo Wei, Jar-Jin Bai, Arthur Chiou, Paul P. Bareil, Pierre-Luc Duval, and Yunlong Sheng, "Dynamic deformation of red blood cell
in Dual-trap Optical Tweezers," Opt. Express 18, 10462-10472 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-10-10462


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