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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 11 — May. 24, 2010
  • pp: 11406–11417

Analysis of a photoacoustic imaging system by the crosstalk matrix and singular value decomposition

Michael Roumeliotis, Robert Z. Stodilka, Mark A. Anastasio, Govind Chaudhary, Hazem Al-Aabed, Eldon Ng, Andrea Immucci, and Jeffrey J.L. Carson  »View Author Affiliations

Optics Express, Vol. 18, Issue 11, pp. 11406-11417 (2010)

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Photoacoustic imaging is a hybrid imaging modality capable of producing contrast similar to optical imaging techniques but with increased penetration depth and resolution in turbid media by encoding the information as acoustic waves. In general, it is important to characterize the performance of a photoacoustic imaging system by parameters such as sensitivity, resolution, and contrast. However, system characterization can extend beyond these metrics by implementing advanced analysis via the crosstalk matrix and singular value decomposition. A method was developed to experimentally measure a matrix that represented the imaging operator for a photoacoustic imaging system. Computations to produce the crosstalk matrix were completed to provide insight into the spatially dependent sensitivity and aliasing for the photoacoustic imaging system. Further analysis of the imaging operator was done via singular value decomposition to estimate the capability of the imaging system to reconstruct objects and the inherent sensitivity to those objects. The results provided by singular value decomposition were compared to SVD results from a de-noised imaging operator to estimate the number of measurable singular vectors for the system. These characterization techniques can be broadly applied to any photoacoustic system and, with regards to the studied system, could be used as a basis for improvements to future iterations.

© 2010 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 15, 2010
Revised Manuscript: May 7, 2010
Manuscript Accepted: May 7, 2010
Published: May 14, 2010

Virtual Issues
Vol. 5, Iss. 10 Virtual Journal for Biomedical Optics

Michael Roumeliotis, Robert Z. Stodilka, Mark A. Anastasio, Govind Chaudhary, Hazem Al-Aabed, Eldon Ng, Andrea Immucci, and Jeffrey J.L. Carson, "Analysis of a photoacoustic imaging system by the crosstalk matrix and singular value decomposition," Opt. Express 18, 11406-11417 (2010)

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