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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 13 — Jun. 21, 2010
  • pp: 13935–13944

In vivo investigation of human cone photoreceptors with SLO/OCT in combination with 3D motion correction on a cellular level

Michael Pircher, Erich Götzinger, Harald Sattmann, Rainer A. Leitgeb, and Christoph K. Hitzenberger  »View Author Affiliations


Optics Express, Vol. 18, Issue 13, pp. 13935-13944 (2010)
http://dx.doi.org/10.1364/OE.18.013935


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Abstract

We present a further improvement of our SLO/OCT imaging system which enables to practically eliminate all eye motion artifacts with a correction accuracy approaching sub-cellular dimensions. Axial eye tracking is achieved by using a hardware based, high speed tracking system that consists of a rapid scanning optical delay line in the reference arm of the interferometer. A software based algorithm is employed to correct for transverse eye motion in a post-processing step. The instrument operates at a frame rate of 40 en-face fps with a field of view of ~1°x1°. Dynamic focusing enables the recording of 3D volumes of the human retina with cellular resolution throughout the entire imaging depth. Several volumes are stitched together to increase the total field of view. Different features of the three dimensional structure of cone photoreceptors are investigated in detail and at different eccentricities from the fovea.

© 2010 OSA

OCIS Codes
(110.6880) Imaging systems : Three-dimensional image acquisition
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(330.5310) Vision, color, and visual optics : Vision - photoreceptors

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 7, 2010
Revised Manuscript: May 25, 2010
Manuscript Accepted: May 25, 2010
Published: June 14, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Michael Pircher, Erich Götzinger, Harald Sattmann, Rainer A. Leitgeb, and Christoph K. Hitzenberger, "In vivo investigation of human cone photoreceptors with SLO/OCT in combination with 3D motion correction on a cellular level," Opt. Express 18, 13935-13944 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-13-13935


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