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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 14 — Jul. 5, 2010
  • pp: 14359–14365

Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints

Jiaying Xiao, Lei Yao, Yao Sun, Eric S. Sobel, Jishan He, and Huabei Jiang  »View Author Affiliations

Optics Express, Vol. 18, Issue 14, pp. 14359-14365 (2010)

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We present for the first time in vivo experimental evidence that quantitative photoacoustic tomography (qPAT) has the potential to detect osteoarthritis (OA) in the finger joints. In this pilot study, 2 OA patients and 4 healthy volunteers were enrolled, and their distal interphalangeal (DIP) joints were examined photoacoustically by a PAT scanner. Tissue absorption coefficient images of all the examined joints, which were unavailable from the conventional PAT, were recovered using our finite element based qPAT approach. The recovered quantitative photoacoustic images revealed significant differences in the tissue absorption coefficient of the joint cavity (cartilage and synovial fluid) between the OA and normal joints.

© 2010 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: May 5, 2010
Revised Manuscript: June 4, 2010
Manuscript Accepted: June 10, 2010
Published: June 21, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Jiaying Xiao, Lei Yao, Yao Sun, Eric S. Sobel, Jishan He, and Huabei Jiang, "Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints," Opt. Express 18, 14359-14365 (2010)

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