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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 14 — Jul. 5, 2010
  • pp: 14416–14429

Skin color independent assessment of aging using skin autofluorescence

Marten Koetsier, Erfan Nur, Han Chunmao, Helen L. Lutgers, Thera P. Links, Andries J. Smit, Gerhard Rakhorst, and Reindert Graaff  »View Author Affiliations


Optics Express, Vol. 18, Issue 14, pp. 14416-14429 (2010)
http://dx.doi.org/10.1364/OE.18.014416


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Abstract

Skin autofluorescence (AF) for the non-invasive assessment of the amount of accumulated tissue Advanced Glycation Endproducts (AGEs) increases with aging. In subjects with darker skin colors, measurements typically result in lower AF values than in subjects with fair skin colors, e.g. due to selective absorption by skin compounds. Our aim was to provide a new method for calculating skin AF, yielding values that are independent of skin color. The deviation of skin AF of healthy subjects with various darker skin types (N = 99) compared to reference values from Caucasians showed to be a function of various parameters that were derived from reflectance and emission spectra in the UV and visible range (adjusted R2 = 80%). Validation of the new algorithm, based on these findings, in a separate dataset (N = 141) showed that results of skin AF can now be obtained to assess skin AGEs independently of skin color.

© 2010 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1610) Medical optics and biotechnology : Clinical applications
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6280) Spectroscopy : Spectroscopy, fluorescence and luminescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 23, 2010
Revised Manuscript: June 7, 2010
Manuscript Accepted: June 7, 2010
Published: June 22, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
M. Koetsier, Erfan Nur, Han Chunmao, Helen L. Lutgers, Thera P. Links, Andries J. Smit, Gerhard Rakhorst, and Reindert Graaff, "Skin color independent assessment of aging using skin autofluorescence," Opt. Express 18, 14416-14429 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-14-14416


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