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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 14 — Jul. 5, 2010
  • pp: 14969–14978

Monitoring photobleaching and hemodynamic responses to HPPH-mediated photodynamic therapy of head and neck cancer: a case report

Ulas Sunar, Daniel Rohrbach, Nestor Rigual, Erin Tracy, Ken Keymel, Michele T. Cooper, Heinz Baumann, and Barbara H. Henderson  »View Author Affiliations


Optics Express, Vol. 18, Issue 14, pp. 14969-14978 (2010)
http://dx.doi.org/10.1364/OE.18.014969


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Abstract

We present initial results obtained during the course of a Phase I clinical trial of 2-1[hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH)-mediated photo-dynamic therapy (PDT) in a head and neck cancer patient. We quantified blood flow, oxygenation and HPPH drug photobleaching before and after therapeutic light treatment by utilizing fast, non-invasive diffuse optical methods. Our results showed that HPPH-PDT induced significant drug photobleaching, and reduction in blood flow and oxygenation suggesting significant vascular and cellular reaction. These changes were accompanied by cross-linking of the signal transducer and activator of transcription 3 (STAT3), a molecular measure for the oxidative photoreaction. These preliminary results suggest diffuse optical spectroscopies permit non-invasive monitoring of PDT in clinical settings of head and neck cancer patients.

© 2010 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 13, 2010
Revised Manuscript: June 21, 2010
Manuscript Accepted: June 23, 2010
Published: June 29, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Ulas Sunar, Daniel Rohrbach, Nestor Rigual, Erin Tracy, Ken Keymel, Michele T. Cooper, Heinz Baumann, and Barbara H. Henderson, "Monitoring photobleaching and hemodynamic responses to HPPH-mediated photodynamic therapy of head and neck cancer: a case report," Opt. Express 18, 14969-14978 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-14-14969


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