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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 18 — Aug. 30, 2010
  • pp: 18625–18632

Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber

Ragnar Olafsson, Daniel R. Bauer, Leonardo G. Montilla, and Russell S. Witte  »View Author Affiliations


Optics Express, Vol. 18, Issue 18, pp. 18625-18632 (2010)
http://dx.doi.org/10.1364/OE.18.018625


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Abstract

A clinical ultrasound scanner and 14 MHz linear array collected real-time photoacoustic images (PAI) during an injection of gold nanorods (GNRs) near the region of a mature PC-3 prostate tumor in mice implanted with a skin flap window chamber. Three dimensional spectroscopic PAI (690-900nm) was also performed to investigate absorption changes near the tumor and enhance specific detection of GNRs. Whereas GNRs improved PAI contrast ( + 18 dB), the photoacoustic spectrum was consistent with the elevated near infrared absorption of GNRs. The versatile imaging platform potentially accelerates development of photoacoustic contrast agents and drug delivery for cancer imaging and therapy.

© 2010 OSA

OCIS Codes
(110.7170) Imaging systems : Ultrasound
(170.1870) Medical optics and biotechnology : Dermatology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 9, 2010
Revised Manuscript: July 23, 2010
Manuscript Accepted: July 28, 2010
Published: August 16, 2010

Virtual Issues
Vol. 5, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Ragnar Olafsson, Daniel R. Bauer, Leonardo G. Montilla, and Russell S. Witte, "Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber," Opt. Express 18, 18625-18632 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-18-18625


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