Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window
                chamber

doi:10.1364/OE.18.018625

Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber

Ragnar Olafsson, Daniel R. Bauer, Leonardo G. Montilla, and Russell S. Witte »View Author Affiliations

Optics Express, Vol. 18, Issue 18, pp. 18625-18632 (2010)
http://dx.doi.org/10.1364/OE.18.018625

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Abstract

A clinical ultrasound scanner and 14 MHz linear array collected real-time photoacoustic images (PAI) during an injection of gold nanorods (GNRs) near the region of a mature PC-3 prostate tumor in mice implanted with a skin flap window chamber. Three dimensional spectroscopic PAI (690-900nm) was also performed to investigate absorption changes near the tumor and enhance specific detection of GNRs. Whereas GNRs improved PAI contrast ( + 18 dB), the photoacoustic spectrum was consistent with the elevated near infrared absorption of GNRs. The versatile imaging platform potentially accelerates development of photoacoustic contrast agents and drug delivery for cancer imaging and therapy.

OCIS Codes
(110.7170) Imaging systems : Ultrasound
(170.1870) Medical optics and biotechnology : Dermatology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 9, 2010
Revised Manuscript: July 23, 2010
Manuscript Accepted: July 28, 2010
Published: August 16, 2010

Virtual Issues
Vol. 5, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Ragnar Olafsson, Daniel R. Bauer, Leonardo G. Montilla, and Russell S. Witte, "Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber," Opt. Express 18, 18625-18632 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-18-18625

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References

A. Jemal, R. Siegel, E. Ward, Y. P. Hao, J. Q. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer J. Clin. 59(4), 225–249 (2009). [CrossRef] [PubMed]
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L. Y. Chen, L. S. Gobar, N. G. Knowles, D. W. Wilson, and H. H. Barrett, “Direct Charged-Particle Imaging System Using an Ultra-Thin Phosphor: Physical Characterization and Dynamic Applications,” IEEE Trans. Nucl. Sci. 56(5), 2628–2635 (2009). [CrossRef]
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R. A. Gatenby, E. T. Gawlinski, A. F. Gmitro, B. Kaylor, and R. J. Gillies, “Acid-mediated tumor invasion: a multidisciplinary study,” Cancer Res. 66(10), 5216–5223 (2006). [CrossRef] [PubMed]
A. F. Gmitro, Y. Lin, and M. Farrokh, “A System for Multi-Modality Optical and MR Imaging of Implanted Window Chambers,” Novel Techniques in Microscopy (NTM), NWD4 (2009).
C. H. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009). [CrossRef] [PubMed]
J. Perez-Juste, I. Pastoriza-Santos, L. M. Liz-Marzan, and P. Mulvaney, “Gold nanorods: Synthesis, characterization and applications,” Coord. Chem. Rev. 249(17-18), 1870–1901 (2005). [CrossRef]
A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007). [CrossRef]
S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009). [CrossRef] [PubMed]
K. Kim, A. Agarwal, A. M. McDonald, R. M. Moore, D. D. Myers, R. S. Witte, S. W. Huang, S. Ashkenazi, M. J. Kaplan, T. W. Wakefield, M. O'Donnell, and N. A. Kotov, “In vivo imaging of inflammatory responses by photoacoustics using cell-targeted gold nanorods (GNR) as contrast agent,” Proc. SPIE 2008 6856, 68560H (2008).
C. K. Liao, S. W. Huang, C. W. Wei, and P. C. Li, “Nanorod-based flow estimation using a high-frame-rate photoacoustic imaging system,” J. Biomed. Opt. 12(6), 064006 (2007). [CrossRef]
D. R. Bauer, R. Olafsson, L. G. Montilla, and R. S. Witte, “In vivo multi-modality photoacoustic and pulse echo tracking of prostate tumor growth using a window chamber,” Proc. SPIE 2010 7564, 75643B (2010).
Laser Institute of America, “American national standard for safe use of lasers Z136.1” (2000).

AAPS J.

E. D. Agdeppa and M. E. Spilker, “A review of imaging agent development,” AAPS J. 11(2), 286–299 (2009). [CrossRef] [PubMed]

Br. J. Cancer

M. W. Dewhirst, E. T. Ong, R. D. Braun, B. Smith, B. Klitzman, S. M. Evans, and D. Wilson, “Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia,” Br. J. Cancer 79(11/12), 1717–1722 (1999). [CrossRef] [PubMed]

CA Cancer J. Clin.

A. Jemal, R. Siegel, E. Ward, Y. P. Hao, J. Q. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer J. Clin. 59(4), 225–249 (2009). [CrossRef] [PubMed]

Cancer Res.

R. A. Gatenby, E. T. Gawlinski, A. F. Gmitro, B. Kaylor, and R. J. Gillies, “Acid-mediated tumor invasion: a multidisciplinary study,” Cancer Res. 66(10), 5216–5223 (2006). [CrossRef] [PubMed]

Coord. Chem. Rev.

J. Perez-Juste, I. Pastoriza-Santos, L. M. Liz-Marzan, and P. Mulvaney, “Gold nanorods: Synthesis, characterization and applications,” Coord. Chem. Rev. 249(17-18), 1870–1901 (2005). [CrossRef]

IEEE Trans. Nucl. Sci.

L. Y. Chen, L. S. Gobar, N. G. Knowles, D. W. Wilson, and H. H. Barrett, “Direct Charged-Particle Imaging System Using an Ultra-Thin Phosphor: Physical Characterization and Dynamic Applications,” IEEE Trans. Nucl. Sci. 56(5), 2628–2635 (2009). [CrossRef]

J. Appl. Phys.

A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007). [CrossRef]

J. Biomed. Opt.

C. K. Liao, S. W. Huang, C. W. Wei, and P. C. Li, “Nanorod-based flow estimation using a high-frame-rate photoacoustic imaging system,” J. Biomed. Opt. 12(6), 064006 (2007). [CrossRef]

J. Cell. Comp. Physiol.

G. H. Algire and J. U. Schlegel, “Circulatory reactions in photodynamic action,” J. Cell. Comp. Physiol. 35(1), 95–110 (1950). [CrossRef]

J. Natl. Cancer Inst.

G. H. Algire and F. Y. Legallais, “Recent developments in the transparent-chamber technique as adapted to the mouse,” J. Natl. Cancer Inst. 10(2), 225–253, 8 (1949). [PubMed]

Nano Lett.

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009). [CrossRef] [PubMed]

Nat. Biotechnol.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999). [CrossRef] [PubMed]

Opt. Lett.

A. Mariampillai, B. A. Standish, E. H. Moriyama, M. Khurana, N. R. Munce, M. K. K. Leung, J. Jiang, A. Cable, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Speckle variance detection of microvasculature using swept-source optical coherence tomography,” Opt. Lett. 33(13), 1530–1532 (2008). [CrossRef] [PubMed]

Phys. Med. Biol.

C. H. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009). [CrossRef] [PubMed]

Other

K. Kim, A. Agarwal, A. M. McDonald, R. M. Moore, D. D. Myers, R. S. Witte, S. W. Huang, S. Ashkenazi, M. J. Kaplan, T. W. Wakefield, M. O'Donnell, and N. A. Kotov, “In vivo imaging of inflammatory responses by photoacoustics using cell-targeted gold nanorods (GNR) as contrast agent,” Proc. SPIE 2008 6856, 68560H (2008).
D. R. Bauer, R. Olafsson, L. G. Montilla, and R. S. Witte, “In vivo multi-modality photoacoustic and pulse echo tracking of prostate tumor growth using a window chamber,” Proc. SPIE 2010 7564, 75643B (2010).
Laser Institute of America, “American national standard for safe use of lasers Z136.1” (2000).
A. F. Gmitro, Y. Lin, and M. Farrokh, “A System for Multi-Modality Optical and MR Imaging of Implanted Window Chambers,” Novel Techniques in Microscopy (NTM), NWD4 (2009).

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