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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 18 — Aug. 30, 2010
  • pp: 19120–19128

Low-cost label-free biosensors using photonic crystals embedded between crossed polarizers

Yousef Nazirizadeh, Uwe Bog, Sylwia Sekula, Timo Mappes, Uli Lemmer, and Martina Gerken  »View Author Affiliations


Optics Express, Vol. 18, Issue 18, pp. 19120-19128 (2010)
http://dx.doi.org/10.1364/OE.18.019120


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Abstract

There is a strong need for low-cost biosensors to enable rapid, on-site analysis of biological, biomedical, or chemical substances. We propose a platform for label-free optical biosensors based on applying the analyte onto a surface-functionalized photonic crystal slab and performing a transmission measurement with two crossed polarization filters. This dark-field approach allows for efficient background suppression as only the photonic crystal guided-mode resonances interacting with the functionalized surface experience significant polarization rotation. We present a compact biosensor demonstrator using a low-cost light emitting diode and a simple photodiode capable of detecting the binding kinetics of a 2.5 nM solution of the protein streptavidin on a biotin-functionalized photonic crystal surface.

© 2010 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(280.4788) Remote sensing and sensors : Optical sensing and sensors
(050.5298) Diffraction and gratings : Photonic crystals

ToC Category:
Photonic Crystals

History
Original Manuscript: May 27, 2010
Revised Manuscript: August 18, 2010
Manuscript Accepted: August 20, 2010
Published: August 25, 2010

Virtual Issues
Vol. 5, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Yousef Nazirizadeh, Uwe Bog, Sylwia Sekula, Timo Mappes, Uli Lemmer, and Martina Gerken, "Low-cost label-free biosensors using photonic crystals embedded between crossed polarizers," Opt. Express 18, 19120-19128 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-18-19120


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