OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 19 — Sep. 13, 2010
  • pp: 19592–19602

Real-time imaging of cardiovascular dynamics and circulating gold nanorods with multispectral optoacoustic tomography

Adrian Taruttis, Eva Herzog, Daniel Razansky, and Vasilis Ntziachristos  »View Author Affiliations


Optics Express, Vol. 18, Issue 19, pp. 19592-19602 (2010)
http://dx.doi.org/10.1364/OE.18.019592


View Full Text Article

Enhanced HTML    Acrobat PDF (1751 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Macroscopic visualization of functional and molecular features of cardiovascular disease is emerging as an important tool in basic research and clinical translation of new diagnostic and therapeutic strategies. We showcase the application of Multispectral Optoacoustic Tomography (MSOT) techniques to noninvasively image different aspects of the mouse cardiovascular system macroscopically in real-time and in vivo, an unprecedented ability compared to optical or optoacoustic (photoacoustic) imaging approaches documented so far. In particular, we demonstrate imaging of the carotid arteries, the aorta and the cardiac wall. We further demonstrate the ability to dynamically visualize circulating gold nanorods that can be used to enhance contrast and be extended to molecular imaging applications. We discuss the potential of this imaging ability in cardiovascular disease (CVD) research and clinical applications.

© 2010 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 29, 2010
Revised Manuscript: June 24, 2010
Manuscript Accepted: July 1, 2010
Published: August 31, 2010

Virtual Issues
Vol. 5, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Adrian Taruttis, Eva Herzog, Daniel Razansky, and Vasilis Ntziachristos, "Real-time imaging of cardiovascular dynamics and circulating gold nanorods with multispectral optoacoustic tomography," Opt. Express 18, 19592-19602 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-19-19592


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. R. A. Kruger, W. L. Kiser, D. R. Reinecke, G. A. Kruger, and K. D. Miller, “Thermoacoustic molecular imaging of small animals,” Mol. Imaging 2(2), 113–123 (2003). [CrossRef] [PubMed]
  2. M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006). [CrossRef]
  3. K. Maslov, G. Stoica, and L. V. Wang, “In vivo dark-field reflection-mode photoacoustic microscopy,” Opt. Lett. 30(6), 625–627 (2005). [CrossRef] [PubMed]
  4. R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy of murine cardiovascular dynamics,” Opt. Express 16(22), 18551–18556 (2008). [CrossRef] [PubMed]
  5. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003). [CrossRef] [PubMed]
  6. S. Manohar, S. E. Vaartjes, J. C. G. van Hespen, J. M. Klaase, F. M. van den Engh, W. Steenbergen, and T. G. van Leeuwen, “Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics,” Opt. Express 15(19), 12277–12285 (2007). [CrossRef] [PubMed]
  7. J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005). [CrossRef] [PubMed]
  8. K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Opt. Lett. 33(9), 929–931 (2008). [CrossRef] [PubMed]
  9. F. Kiessling, D. Razansky, and F. Alves, “Anatomical and microstructural imaging of angiogenesis,” Eur. J. Nucl. Med. Mol. Imaging (2010). [CrossRef] [PubMed]
  10. J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007). [CrossRef]
  11. H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90(5), 053901 (2007). [CrossRef]
  12. S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express 16(5), 3362–3367 (2008). [CrossRef] [PubMed]
  13. M. L. Li, J. T. Oh, X. Xie, G. Ku, W. Wang, C. Li, G. Lungu, G. Stoica, and L. V. Wang, “Simultaneous molecular and hypoxia imaging of brain tumors in vivo using spectroscopic photoacoustic tomography,” Proc. IEEE 96(3), 481–489 (2008). [CrossRef]
  14. D. Razansky, C. Vinegoni, and V. Ntziachristos, “Multispectral photoacoustic imaging of fluorochromes in small animals,” Opt. Lett. 32(19), 2891–2893 (2007). [CrossRef] [PubMed]
  15. D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009). [CrossRef]
  16. A. De La Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008). [CrossRef] [PubMed]
  17. M. Eghtedari, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, “High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system,” Nano Lett. 7(7), 1914–1918 (2007). [CrossRef] [PubMed]
  18. P. C. Li, C. R. C. Wang, D. B. Shieh, C. W. Wei, C. K. Liao, C. Poe, S. Jhan, A. A. Ding, and Y. N. Wu, “In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods,” Opt. Express 16(23), 18605–18615 (2008). [CrossRef]
  19. V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev. 110(5), 2783–2794 (2010). [CrossRef] [PubMed]
  20. H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009). [CrossRef]
  21. R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express 17(24), 21414–21426 (2009). [CrossRef] [PubMed]
  22. J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009). [CrossRef] [PubMed]
  23. K. H. Song and L. V. Wang, “Noninvasive photoacoustic imaging of the thoracic cavity and the kidney in small and large animals,” Med. Phys. 35(10), 4524–4529 (2008). [CrossRef] [PubMed]
  24. A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett. 35(14), 2475–2477 (2010). [CrossRef] [PubMed]
  25. Laser Institute of America, “American National Standard for Safe use of Lasers ANSI Z136. 1-2000,” American National Standard Institute (2000).
  26. D. Razansky, J. Baeten, and V. Ntziachristos, “Sensitivity of molecular target detection by multispectral optoacoustic tomography (MSOT),” Med. Phys. 36(3), 939–945 (2009). [CrossRef] [PubMed]
  27. A. Rosenthal, D. Razansky, and V. Ntziachristos, “Fast semi-analytical model-based acoustic inversion for quantitative optoacoustic tomography,” IEEE Trans. Med. Imaging 29(6), 1275–1285 (2010). [CrossRef] [PubMed]
  28. R. A. Kruger, D. R. Reinecke, and G. A. Kruger, “Thermoacoustic computed tomography--technical considerations,” Med. Phys. 26(9), 1832–1837 (1999). [CrossRef] [PubMed]
  29. C. K. Zarins, D. P. Giddens, B. K. Bharadvaj, V. S. Sottiurai, R. F. Mabon, and S. Glagov, “Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress,” Circ. Res. 53(4), 502–514 (1983). [PubMed]
  30. K. H. Song, C. Kim, K. Maslov, and L. V. Wang, “Noninvasive in vivo spectroscopic nanorod-contrast photoacoustic mapping of sentinel lymph nodes,” Eur. J. Radiol. 70(2), 227–231 (2009). [CrossRef] [PubMed]
  31. A. Agarwal, S. W. Huang, M. O’Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007). [CrossRef]
  32. S. S. Chang, C. W. Shih, C. D. Chen, W. C. Lai, and C. R. C. Wang, “The shape transition of gold nanorods,” Langmuir 15(3), 701–709 (1999). [CrossRef]
  33. C. L. Didychuk, P. Ephrat, A. Chamson-Reig, S. L. Jacques, and J. J. L. Carson, “Depth of photothermal conversion of gold nanorods embedded in a tissue-like phantom,” Nanotechnology 20(19), 195102 (2009). [CrossRef] [PubMed]
  34. F. A. Jaffer, P. Libby, and R. Weissleder, “Molecular imaging of cardiovascular disease,” Circulation 116(9), 1052–1061 (2007). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Supplementary Material


» Media 1: MOV (3077 KB)     
» Media 2: MOV (1186 KB)     

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited