OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 24 — Nov. 22, 2010
  • pp: 24395–24404

Reference spectrum extraction and fixed-pattern noise removal in optical coherence tomography

Sucbei Moon, Sang-Won Lee, and Zhongping Chen  »View Author Affiliations


Optics Express, Vol. 18, Issue 24, pp. 24395-24404 (2010)
http://dx.doi.org/10.1364/OE.18.024395


View Full Text Article

Enhanced HTML    Acrobat PDF (1203 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We present a new signal processing method that extracts the reference spectrum information from an acquired optical coherence tomography (OCT) image without a separate calibration step of reference spectrum measurement. The reference spectrum is used to remove the fixed-pattern noise that is a characteristic artifact of Fourier-domain OCT schemes. It was found that the conventional approach based on an averaged spectrum, or mean spectrum, is prone to be influenced by the high-amplitude data points whose statistical distribution is hardly randomized. Thus, the conventional mean-spectrum subtraction method cannot completely eliminate the artifact but may leave residual horizontal lines in the final image. This problem was avoided by utilizing an advanced statistical analysis tool of the median A-line. The reference A-line was obtained by taking a complex median of each horizontal-line data. As an optional method of high-speed calculation, we also propose a minimum-variance mean A-line that can be calculated from an image by a collection of mean A-line values taken from a horizontal segment whose complex variance of the data points is the minimum. By comparing the images processed by those methods, it was found that our new processing schemes of the median-line subtraction and the minimum-variance mean-line subtraction successfully suppressed the fixed-pattern noise. The inverse Fourier transform of the obtained reference A-line well matched the reference spectrum obtained by a physical measurement as well.

© 2010 OSA

OCIS Codes
(100.2000) Image processing : Digital image processing
(110.4500) Imaging systems : Optical coherence tomography
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Imaging Systems

History
Original Manuscript: September 2, 2010
Revised Manuscript: October 15, 2010
Manuscript Accepted: October 21, 2010
Published: November 8, 2010

Citation
Sucbei Moon, Sang-Won Lee, and Zhongping Chen, "Reference spectrum extraction and fixed-pattern noise removal in optical coherence tomography," Opt. Express 18, 24395-24404 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-24-24395


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express 11(8), 889–894 (2003), http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-8-889 . [CrossRef] [PubMed]
  2. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett. 28(21), 2067–2069 (2003), http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-28-21-2067 . [CrossRef] [PubMed]
  3. J. F. de Boer, “Spectral/Fourier domain optical coherence tomography,” in Optical Coherence Tomography, Technology and Applications, Wolfgang Drexler, and James G. Fujimoto, eds. (Springer, 2008), pp. 147–175.
  4. S. Yun, G. Tearney, J. de Boer, N. Iftimia, and B. Bouma, “High-speed optical frequency-domain imaging,” Opt. Express 11(22), 2953–2963 (2003), http://www.opticsinfobase.org/abstract.cfm?URI=oe-11-22-2953 . [CrossRef] [PubMed]
  5. R. A. Leitgeb, and M. Wojtkowski, “Complex and coherent noise free Fourier domain optical coherence tomography,” in Optical Coherence Tomography, Technology and Applications, Wolfgang Drexler, and James G. Fujimoto, eds. (Springer, 2008), pp. 177–207.
  6. N. Nassif, B. Cense, B. Park, M. Pierce, S. Yun, B. Bouma, G. Tearney, T. Chen, and J. de Boer, “In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve,” Opt. Express 12(3), 367–376 (2004), http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-12-3-367 . [CrossRef] [PubMed]
  7. R. Tripathi, N. Nassif, J. S. Nelson, B. H. Park, and J. F. de Boer, “Spectral shaping for non-Gaussian source spectra in optical coherence tomography,” Opt. Lett. 27(6), 406–408 (2002), http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-27-6-406 . [CrossRef]
  8. C. C. Rosa and A. G. Podoleanu, “Limitation of the achievable signal-to-noise ratio in optical coherence tomography due to mismatch of the balanced receiver,” Appl. Opt. 43(25), 4802–4815 (2004), http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-43-25-4802 . [CrossRef] [PubMed]
  9. R. Langley, Practical Statistics (Dover Publications, 1971).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4 Fig. 5
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited