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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 25 — Dec. 6, 2010
  • pp: 25973–25986

Quantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy

Fenghua Tian, Mauricio R. Delgado, Sameer C. Dhamne, Bilal Khan, George Alexandrakis, Mario I. Romero, Linsley Smith, Dahlia Reid, Nancy J. Clegg, and Hanli Liu  »View Author Affiliations

Optics Express, Vol. 18, Issue 25, pp. 25973-25986 (2010)

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Cerebral palsy (CP) is the most common motor disorder in children. Currently available neuroimaging techniques require complete body confinement and steadiness and thus are extremely difficult for pediatric patients. Here, we report the use and quantification of functional near infrared spectroscopy (fNIRS) to investigate the functional reorganization of the sensorimotor cortex in children with hemiparetic CP. Ten of sixteen children with congenital hemiparesis were measured during finger tapping tasks and compared with eight of sixteen age-matched healthy children, with an overall measurement success rate of 60%. Spatiotemporal analysis was introduced to quantify the motor activation and brain laterality. Such a quantitative approach reveals a consistent, contralateral motor activation in healthy children at 7 years of age or older. In sharp contrast, children with congenital hemiparesis exhibit all three of contralateral, bilateral and ipsilateral motor activations, depending on specific ages of the pediatric subjects. This study clearly demonstrates the feasibility of fNIRS to be utilized for investigating cortical reorganization in children with CP or other cortical disorders.

© 2010 OSA

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.6960) Medical optics and biotechnology : Tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 23, 2010
Revised Manuscript: September 23, 2010
Manuscript Accepted: November 16, 2010
Published: November 30, 2010

Fenghua Tian, Mauricio R. Delgado, Sameer C. Dhamne, Bilal Khan, George Alexandrakis, Mario I. Romero, Linsley Smith, Dahlia Reid, Nancy J. Clegg, and Hanli Liu, "Quantification of functional near infrared
spectroscopy to assess cortical reorganization 
in children with cerebral palsy," Opt. Express 18, 25973-25986 (2010)

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