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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 25 — Dec. 6, 2010
  • pp: 26535–26549

Three-wavelength murine photoplethysmography for estimation of vascular gold nanorod concentration

Gregory J. Michalak, Jon A. Schwartz, Glenn P. Goodrich, and D. Patrick O’Neal  »View Author Affiliations


Optics Express, Vol. 18, Issue 25, pp. 26535-26549 (2010)
http://dx.doi.org/10.1364/OE.18.026535


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Abstract

Nanoparticle-assisted photo-thermal (NAPT) ablation has become a new and attractive modality for the treatment of cancerous tumors. This therapy exploits the passive accumulation of intravenously delivered optically resonant metal nanoparticles into tumors, however, the circulating bioavailability of these particles is often unknown. We present a non-invasive optical device capable of monitoring the circulation of optically resonant gold nanorods. The device, referred to as a pulse photometer, uses the technique of multi-wavelength photoplethysmography. We simultaneously report the circulation of gold nanorods and oximetry for six hours post-injection in mice with no anesthesia and remove the probe when not collecting data. The instrument shows good agreement (R2=0.903, n=30) with ex vivo spectrophotometric analysis of blood samples. The real-time feedback provided has a strong potential for reducing variability and thus improving the efficacy of similar clinical therapies.

© 2010 OSA

OCIS Codes
(170.1460) Medical optics and biotechnology : Blood gas monitoring
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(350.4238) Other areas of optics : Nanophotonics and photonic crystals

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 26, 2010
Revised Manuscript: November 9, 2010
Manuscript Accepted: November 18, 2010
Published: December 3, 2010

Citation
Gregory J. Michalak, Jon A. Schwartz, Glenn P. Goodrich, and D. Patrick O’Neal, "Three-wavelength murine photoplethysmography for estimation of vascular gold nanorod concentration," Opt. Express 18, 26535-26549 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-25-26535


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