OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 25 — Dec. 6, 2010
  • pp: 26754–26759

Opto-electrophoretic detection of bio-molecules using conducting chalcogenide glass sensors

Zhiyong Yang, Megan K. Fah, Kelly A. Reynolds, Jonathan D. Sexton, Mark R. Riley, Marie-Laure Anne, Bruno Bureau, and Pierre Lucas  »View Author Affiliations

Optics Express, Vol. 18, Issue 25, pp. 26754-26759 (2010)

View Full Text Article

Enhanced HTML    Acrobat PDF (1108 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Novel telluride glasses with high electrical conductivity, wide infrared transparency and good resistance to crystallization are used to design an opto-electrophoretic sensor for detection and identification of hazardous microorganisms. The sensor is based on an attenuated total reflectance element made of Ge-As-Te glass that serves as both an optical sensing zone and an electrode for driving the migration of bio-molecules within the evanescent wave of the sensor. An electric field is applied between the optical element and a counter electrode in order to induce the migration of bio-molecules carrying surface charges. The effect of concentration and applied voltage is tested and the migration effect is shown to be reversible upon switching the electric field. The collected signal is of high quality and can be used to identify different bacterial genus through statistical spectral analysis. This technique therefore provides the ability to detect hazardous microorganisms with high specificity and high sensitivity in aqueous environments. This has great potential for online monitoring of water quality.

© 2010 OSA

OCIS Codes
(160.2750) Materials : Glass and other amorphous materials
(300.6340) Spectroscopy : Spectroscopy, infrared
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Chalcogenide Glass

Original Manuscript: August 27, 2010
Revised Manuscript: October 6, 2010
Manuscript Accepted: October 6, 2010
Published: December 6, 2010

Virtual Issues
Chalcogenide Glass (2010) Optics Express

Zhiyong Yang, Megan K. Fah, Kelly A. Reynolds, Jonathan D. Sexton, Mark R. Riley, Marie-Laure Anne, Bruno Bureau, and Pierre Lucas, "Opto-electrophoretic detection of bio-molecules using conducting chalcogenide glass sensors," Opt. Express 18, 26754-26759 (2010)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. D. Naumann, D. Helm, and H. Labischinski, “Microbiological characterizations by FT-IR spectroscopy,” Nature 351(6321), 81–82 (1991). [CrossRef] [PubMed]
  2. M. Diem, S. Boydston-White, and L. Chiriboga, “Infrared Spectroscopy of Cells and Tissues: Shinning Light onto a Novel Subject,” Appl. Spectrosc. 53(4), 148–161 (1999). [CrossRef]
  3. D. Naumann, “Infrared spectroscopy in microbiology,” in Encyclopedia of analytical chemistry, R. A. Meyers, ed. (John Wiley & Sons Ltd, Chichester, 2000), p. 102.
  4. P. Lucas, M. R. Riley, C. Boussard-Plédel, and B. Bureau, “Advances in chalcogenide fiber evanescent wave biochemical sensing,” Anal. Biochem. 351(1), 1–10 (2006). [CrossRef]
  5. Y. Raichlin and A. Katzir, “Fiber-optic evanescent wave spectroscopy in the middle infrared,” Appl. Spectrosc. 62(2), 55–72 (2008). [CrossRef]
  6. B. Mizaikoff, “Mid-IR fiber-optic sensors,” Anal. Chem. 75(11), 258A–267A (2003). [CrossRef] [PubMed]
  7. Z. Yang, A. A. Wilhelm, and P. Lucas, “High-conductivity tellurium-based infrared transmitting glasses and their suitability for bio-optical detection,” J. Am. Ceram. Soc. 93, 1941–1944 (2010).
  8. A. A. Wilhelm, P. Lucas, D. L. DeRosa, and M. R. Riley, “Biocompatibility of Te–As–Se glass fibers for cell-based bio-optic infrared sensors,” J. Mater. Res. 22(4), 1098–1104 (2007). [CrossRef]
  9. P. Lucas, D. Le Coq, C. Juncker, J. Collier, D. E. Boesewetter, C. Boussard-Plédel, B. Bureau, and M. R. Riley, “Evaluation of toxic agent effects on lung cells by fiber evanescent wave spectroscopy,” Appl. Spectrosc. 59(1), 1–9 (2005). [CrossRef] [PubMed]
  10. P. G. Righetti and T. Caravaggio, “Isoelectric points and molecular weights of proteins: A table,” J. Chromatogr. A 127(1), 1–28 (1976). [CrossRef]
  11. H. Miörner, P. A. Albertsson, and G. Kronvall, “Isoelectric points and surface hydrophobicity of Gram-positive cocci as determined by cross-partition and hydrophobic affinity partition in aqueous two-phase systems,” Infect. Immun. 36(1), 227–234 (1982). [PubMed]
  12. J. Keirsse, B. Bureau, C. Boussard-Pledel, P. Leroyer, M. Ropert, V. Dupont, M. L. Anne, C. Ribault, O. Sire, O. Loreal, and J. L. Adam, “Chalcogenide glass fibers for in-situ infrared spectroscopy in biology and medicine,” Proc. SPIE 5459, 61–68 (2004). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited