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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 26 — Dec. 20, 2010
  • pp: 27560–27566

Fabrication of glucose fiber sensor based on immobilized GOD technique for rapid measurement

Ting-Qian Lin, Yin-Lin Lu, and Cheng-Chih Hsu  »View Author Affiliations

Optics Express, Vol. 18, Issue 26, pp. 27560-27566 (2010)

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The concentration and pH value of the immobilized glucose oxidase (GOD) are critical parameters in a glucose sensor. In this study, we develop a glucose fiber sensor integrated with heterodyne interferometry to measure the phase difference arising from the chemical reaction between glucose and GOD. Our studies show that the response time and resolution of this sensor will be strongly affected by the pH and concentration properties of GOD. In addition, the results show good linearity between the calibration curve for the glucose solution and serum based sample. The response time of this sensor can be shorter than 3 seconds and best resolutions are 0.1 and 0.136 mg/dl for glucose solution and serum based sample, respectively.

© 2010 OSA

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:

Original Manuscript: September 30, 2010
Revised Manuscript: November 10, 2010
Manuscript Accepted: November 11, 2010
Published: December 15, 2010

Ting-Qian Lin, Yin-Lin Lu, and Cheng-Chih Hsu, "Fabrication of glucose fiber sensor based on immobilized GOD technique for rapid measurement," Opt. Express 18, 27560-27566 (2010)

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  1. D. Jiang, E. Liu, X. Chen, and J. Huang, “Design and properties study of fiber optics glucose biosensor,” Chin. Opt. Lett. 1, 108–110 (2003).
  2. B. Ganesh and T. K. Radhakrishnan, “Employment of fluorescence quenching for the determination of oxygen and glucose,” Sensors Transducers 60, 439–445 (2005).
  3. Z. Rosenzweig and R. Kopelman, “Analytical properties of miniaturized oxygen and glucose fiber optics sensor,” Sens. Act. B 35-36, 475–483 (1996). [CrossRef]
  4. M. Portaccio, M. Lepore, B. D. Ventura, O. Stoilova, N. Manolova, I. Rashkov, and D. G. Mita, “Fiber-optic glucose biosensor based on glucose oxidase immobilized in a silica gel matrix,” J. Sol-Gel Sci. Technol. 50, 437–448 (2009). [CrossRef]
  5. M. H. Chiu, S. F. Wand, and R. S. Chang, “D-type biosensor based on surface-plasmon resonance technology and heterodyne interferometry,” Opt. Lett. 30, 233–235 (2005). [CrossRef] [PubMed]
  6. H. Wang, J. Huang, Y. Yuan, L. Ding, and D. Fan, “Multifunctional sol-gel sensing membrane for fiber optics glucose sensor,” Proc. SPIE 7673, 767310-1- 767310-7(2010).
  7. P. Yeh, Optical Waves in Layered Media, (John Wiley & Sons, 1991), chaps. 9 and 11.
  8. Y. L. Yeh, “Real-time measurement of glucose concentration and average refractive index using a laser interferometer,” Opt. Lasers Eng. 46, 666–670 (2008). [CrossRef]
  9. S. Binu, V. P. Mahadevan Pillai, V. Pradeepkumar, B. B. Padhy, C. S. Joseph, and N. Chandrasekaran, “Fibre optic glucose sensor,” Mater. Sci. Eng. C 29, 183–186 (2009). [CrossRef]
  10. W. J. Ho, J. S. Chen, M. D. Ker, T. K. Wu, C. Y. Wu, Y. S. Yang, Y. K. Li, and C. J. Yuan, “Fabrication of a miniature CMOS-based optical biosensor,” Biosens. Bioelectron. 22, 3008–3013 (2007). [CrossRef] [PubMed]
  11. P. Trinder, “Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor,” Ann. Clin. Biochem. 6, 24–27 (1969).
  12. D. Barham and P. Trinder, “An improved colour reagent for the determination of blood glucose by the oxidase system,” Analyst (Lond.) 97, 142–145 (1972). [CrossRef]
  13. C. C. Hsu and D. C. Su, “Method for determining the optic axis and (ne, no) of a birefringent crystal,” Appl. Opt. 41, 3936–3940 (2002). [CrossRef] [PubMed]

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