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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 3 — Feb. 1, 2010
  • pp: 3079–3092

In vitro characterization of cardiac radiofrequency ablation lesions using optical coherence tomography

Christine P. Fleming, Kara J. Quan, Hui Wang, Guy Amit, and Andrew M. Rollins  »View Author Affiliations


Optics Express, Vol. 18, Issue 3, pp. 3079-3092 (2010)
http://dx.doi.org/10.1364/OE.18.003079


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Abstract

Currently, cardiac radiofrequency ablation (RFA) is guided by indirect signals. We demonstrate optical coherence tomography (OCT) characterization of RFA lesions within swine ventricular wedges. Untreated tissue exhibited a consistent birefringence artifact within OCT images due to the organized myocardium, which was not present in treated tissue. Birefringence artifacts were detected by filtering with a Laplacian of Gaussian (LoG) to quantify gradient strength. The gradient strength distinguished RFA lesions from untreated sites (p=5.93×10-15) with a sensitivity and specificity of 94.5% and 86.7% respectively. This study demonstrates the potential of OCT for monitoring cardiac RFA, confirming lesion formation and providing feedback to avoid complications.

© 2010 Optical Society of America

OCIS Codes
(170.1020) Medical optics and biotechnology : Ablation of tissue
(170.1610) Medical optics and biotechnology : Clinical applications
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 28, 2009
Revised Manuscript: December 21, 2009
Manuscript Accepted: December 22, 2009
Published: January 28, 2010

Virtual Issues
Vol. 5, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Christine P. Fleming, Kara J. Quan, Hui Wang, Guy Amit, and Andrew M. Rollins, "In vitro characterization of cardiac radiofrequency ablation lesions using optical coherence tomography," Opt. Express 18, 3079-3092 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-3-3079


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