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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 5 — Mar. 1, 2010
  • pp: 4889–4897

Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imaging

Bo Wang, Jimmy L. Su, James Amirian, Silvio H. Litovsky, Richard Smalling, and Stanislav Emelianov  »View Author Affiliations

Optics Express, Vol. 18, Issue 5, pp. 4889-4897 (2010)

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Lipid is a common constituent in atherosclerotic plaques. The location and area of the lipid region is closely related to the progression of the disease. Intravascular photoacoustic (IVPA) imaging, a minimally invasive imaging modality, can spatially resolve the optical absorption property of arterial tissue. Based on the distinct optical absorption spectrum of fat in the near infrared wavelength range, spectroscopic IVPA imaging may distinguish lipid from other water-based tissue types in the atherosclerotic artery. In this study, a bench-top spectroscopic IVPA imaging system was used to ex-vivo image both atherosclerotic and normal rabbit aortas. By combing the spectroscopic IVPA image with the intravascular ultrasound (IVUS) image, lipid regions in the aorta were identified. The results demonstrated that IVUS-guided spectroscopic IVPA imaging is a promising tool to differentiate lipid in atherosclerosis.

© 2010 OSA

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 18, 2009
Revised Manuscript: February 19, 2010
Manuscript Accepted: February 20, 2010
Published: February 24, 2010

Virtual Issues
Vol. 5, Iss. 6 Virtual Journal for Biomedical Optics

Bo Wang, Jimmy L. Su, James Amirian, Silvio H. Litovsky, Richard Smalling, and Stanislav Emelianov, "Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imaging," Opt. Express 18, 4889-4897 (2010)

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