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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 6 — Mar. 15, 2010
  • pp: 6300–6314

Principal component analysis of dynamic fluorescence diffuse optical tomography images

Xin Liu, Daifa Wang, Fei Liu, and Jing Bai  »View Author Affiliations


Optics Express, Vol. 18, Issue 6, pp. 6300-6314 (2010)
http://dx.doi.org/10.1364/OE.18.006300


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Abstract

Challenges remain in resolving drug distributions within small animals utilizing fluorescence diffuse optical tomography (FDOT). In this paper, we present a new method for detecting and visualizing organs with different kinetics utilizing principal component analysis (PCA). Indocynaine green (ICG) metabolic processes are simulated and imaged using FDOT. When applied to the time series of generated FDOT images, PCA provides a set of the principal components (PCs) which can represent spatial patterns associated with different kinetic behavior. Simulation and experiment studies are both performed to validate the performance of the proposed algorithm. The results suggest that we are able to extract and illustrate changes in ICG kinetic behavior between the heart and the lungs.

© 2010 OSA

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 10, 2009
Revised Manuscript: February 6, 2010
Manuscript Accepted: March 10, 2010
Published: March 12, 2010

Virtual Issues
Vol. 5, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Xin Liu, Daifa Wang, Fei Liu, and Jing Bai, "Principal component analysis of dynamic fluorescence diffuse optical tomography images," Opt. Express 18, 6300-6314 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-6-6300


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