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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 9 — Apr. 26, 2010
  • pp: 8867–8878

Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy

Yun-Sheng Chen, Wolfgang Frey, Seungsoo Kim, Kimberly Homan, Pieter Kruizinga, Konstantin Sokolov, and Stanislav Emelianov  »View Author Affiliations

Optics Express, Vol. 18, Issue 9, pp. 8867-8878 (2010)

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Photothermal stability and, therefore, consistency of both optical absorption and photoacoustic response of the plasmonic nanoabsorbers is critical for successful photoacoustic image-guided photothermal therapy. In this study, silica-coated gold nanorods were developed as a multifunctional molecular imaging and therapeutic agent suitable for image-guided photothermal therapy. The optical properties and photothermal stability of silica-coated gold nanorods under intense irradiation with nanosecond laser pulses were investigated by UV-Vis spectroscopy and transmission electron microscopy. Silica-coated gold nanorods showed increased photothermal stability and retained their superior optical properties under much higher fluences. The changes in photoacoustic response of PEGylated and silica-coated nanorods under laser pulses of various fluences were compared. The silica-coated gold nanorods provide a stable photoacoustic signal, which implies better imaging capabilities and make silica-coated gold nanorods a promising imaging and therapeutic nano-agent for photoacoustic imaging and image-guided photothermal therapy.

© 2010 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: February 18, 2010
Revised Manuscript: March 29, 2010
Manuscript Accepted: March 30, 2010
Published: April 13, 2010

Virtual Issues
Vol. 5, Iss. 9 Virtual Journal for Biomedical Optics

Yun-Sheng Chen, Wolfgang Frey, Seungsoo Kim, Kimberly Homan, Pieter Kruizinga, Konstantin Sokolov, and Stanislav Emelianov, "Enhanced thermal stability of silica-coated 
gold nanorods for photoacoustic imaging and image-guided therapy," Opt. Express 18, 8867-8878 (2010)

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