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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 9 — Apr. 26, 2010
  • pp: 8923–8936

3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea

Mingtao Zhao, Anthony N Kuo, and Joseph A Izatt  »View Author Affiliations


Optics Express, Vol. 18, Issue 9, pp. 8923-8936 (2010)
http://dx.doi.org/10.1364/OE.18.008923


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Abstract

Capable of three-dimensional imaging of the cornea with micrometer-scale resolution, spectral domain-optical coherence tomography (SDOCT) offers potential advantages over Placido ring and Scheimpflug photography based systems for accurate extraction of quantitative keratometric parameters. In this work, an SDOCT scanning protocol and motion correction algorithm were implemented to minimize the effects of patient motion during data acquisition. Procedures are described for correction of image data artifacts resulting from 3D refraction of SDOCT light in the cornea and from non-idealities of the scanning system geometry performed as a pre-requisite for accurate parameter extraction. Zernike polynomial 3D reconstruction and a recursive half searching algorithm (RHSA) were implemented to extract clinical keratometric parameters including anterior and posterior radii of curvature, central cornea optical power, central corneal thickness, and thickness maps of the cornea. Accuracy and repeatability of the extracted parameters obtained using a commercial 859nm SDOCT retinal imaging system with a corneal adapter were assessed using a rigid gas permeable (RGP) contact lens as a phantom target. Extraction of these parameters was performed in vivo in 3 patients and compared to commercial Placido topography and Scheimpflug photography systems. The repeatability of SDOCT central corneal power measured in vivo was 0.18 Diopters, and the difference observed between the systems averaged 0.1 Diopters between SDOCT and Scheimpflug photography, and 0.6 Diopters between SDOCT and Placido topography.

© 2010 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(190.5330) Nonlinear optics : Photorefractive optics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 11, 2010
Revised Manuscript: April 6, 2010
Manuscript Accepted: April 6, 2010
Published: April 14, 2010

Virtual Issues
Vol. 5, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Mingtao Zhao, Anthony N Kuo, and Joseph A Izatt, "3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea," Opt. Express 18, 8923-8936 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-9-8923


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