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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 9 — Apr. 26, 2010
  • pp: 9181–9191

Scatterer size-based analysis of optical coherence tomography images using spectral estimation techniques

Andreas Kartakoullis, Evgenia Bousi, and Costas Pitris  »View Author Affiliations


Optics Express, Vol. 18, Issue 9, pp. 9181-9191 (2010)
http://dx.doi.org/10.1364/OE.18.009181


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Abstract

A novel spectral analysis technique of OCT images is demonstrated in this paper for classification and scatterer size estimation. It is based on SOCT autoregressive spectral estimation techniques and statistical analysis. Two different statistical analysis methods were applied to OCT images acquired from tissue phantoms, the first method required prior information on the sample for variance analysis of the spectral content. The second method used k-means clustering without prior information for the sample. The results are very encouraging and indicate that the spectral content of OCT signals can be used to estimate scatterer size and to classify dissimilar areas in phantoms and tissues with sensitivity and specificity of more than 90%.

© 2010 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(140.3600) Lasers and laser optics : Lasers, tunable
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.0290) Scattering : Scattering
(290.4020) Scattering : Mie theory

ToC Category:
Imaging Systems

History
Original Manuscript: February 17, 2010
Revised Manuscript: April 7, 2010
Manuscript Accepted: April 12, 2010
Published: April 16, 2010

Virtual Issues
Vol. 5, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Andreas Kartakoullis, Evgenia Bousi, and Costas Pitris, "Scatterer size-based analysis of optical coherence tomography images using spectral estimation techniques," Opt. Express 18, 9181-9191 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-9-9181


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