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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 11 — May. 23, 2011
  • pp: 10536–10552

Optical design and imaging performance testing of a 9.6-mm diameter femtosecond laser microsurgery probe

Christopher L. Hoy, Onur Ferhanoğlu, Murat Yildirim, Wibool Piyawattanametha, Hyejun Ra, Olav Solgaard, and Adela Ben-Yakar  »View Author Affiliations

Optics Express, Vol. 19, Issue 11, pp. 10536-10552 (2011)

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We present the optical design of a 9.6-mm diameter fiber-coupled probe for combined femtosecond laser microsurgery and nonlinear optical imaging. Towards enabling clinical use, we successfully reduced the dimensions of our earlier 18-mm microsurgery probe by half, while improving optical performance. We use analytical and computational models to optimize the miniaturized lens system for off-axis scanning aberrations. The optimization reveals that the optical system can be aberration-corrected using simple aspheric relay lenses to achieve diffraction-limited imaging resolution over a large field of view. Before moving forward with custom lenses, we have constructed the 9.6-mm probe using off-the-shelf spherical relay lenses and a 0.55 NA aspheric objective lens. In addition to reducing the diameter by nearly 50% and the total volume by 5 times, we also demonstrate improved lateral and axial resolutions of 1.27 µm and 13.5 µm, respectively, compared to 1.64 µm and 16.4 µm in our previous work. Using this probe, we can successfully image various tissue samples, such as rat tail tendon that required 2-3 × lower laser power than the current state-of-the-art. With further development, image-guided, femtosecond laser microsurgical probes such as this one can enable physicians to achieve the highest level of surgical precision anywhere inside the body.

© 2011 OSA

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(220.4830) Optical design and fabrication : Systems design
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 26, 2011
Revised Manuscript: February 23, 2011
Manuscript Accepted: March 18, 2011
Published: May 13, 2011

Virtual Issues
Vol. 6, Iss. 6 Virtual Journal for Biomedical Optics

Christopher L. Hoy, Onur Ferhanoğlu, Murat Yildirim, Wibool Piyawattanametha, Hyejun Ra, Olav Solgaard, and Adela Ben-Yakar, "Optical design and imaging performance testing of a 9.6-mm diameter femtosecond laser microsurgery probe," Opt. Express 19, 10536-10552 (2011)

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