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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 12 — Jun. 6, 2011
  • pp: 11490–11506

Feasibility of U-curve method to select the regularization parameter for fluorescence diffuse optical tomography in phantom and small animal studies

Judit Chamorro-Servent, Juan Aguirre, Jorge Ripoll, Juan José Vaquero, and Manuel Desco  »View Author Affiliations


Optics Express, Vol. 19, Issue 12, pp. 11490-11506 (2011)
http://dx.doi.org/10.1364/OE.19.011490


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Abstract

When dealing with ill-posed problems such as fluorescence diffuse optical tomography (fDOT) the choice of the regularization parameter is extremely important for computing a reliable reconstruction. Several automatic methods for the selection of the regularization parameter have been introduced over the years and their performance depends on the particular inverse problem. Herein a U-curve-based algorithm for the selection of regularization parameter has been applied for the first time to fDOT. To increase the computational efficiency for large systems an interval of the regularization parameter is desirable. The U-curve provided a suitable selection of the regularization parameter in terms of Picard’s condition, image resolution and image noise. Results are shown both on phantom and mouse data.

© 2011 OSA

OCIS Codes
(100.3190) Image processing : Inverse problems
(110.6960) Imaging systems : Tomography
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(260.2510) Physical optics : Fluorescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 11, 2011
Revised Manuscript: April 24, 2011
Manuscript Accepted: April 25, 2011
Published: May 31, 2011

Virtual Issues
Vol. 6, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Judit Chamorro-Servent, Juan Aguirre, Jorge Ripoll, Juan José Vaquero, and Manuel Desco, "Feasibility of U-curve method to select the regularization parameter for fluorescence diffuse optical tomography in phantom and small animal studies," Opt. Express 19, 11490-11506 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-12-11490


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