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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 16 — Aug. 1, 2011
  • pp: 14903–14912

Plasmonic chiral contrast agents for optical coherence tomography: numerical study

Kalpesh B. Mehta and Nanguang Chen  »View Author Affiliations


Optics Express, Vol. 19, Issue 16, pp. 14903-14912 (2011)
http://dx.doi.org/10.1364/OE.19.014903


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Abstract

Optical coherence tomography (OCT) is a widely used morphological imaging modality. Various contrast agents, which change localized optical properties, are used to extend the applicability of OCT, where intrinsic contrast is not sufficient. In this paper we propose the use of a dual-rod gold nano-structure as a polarization sensitive contrast agent. Using numerical simulation, we demonstrated that the proposed structure has tunable chiral response. Enhanced cross-section due to Plasmon resonance in gold nanoparticles, along with the chiral behavior can provide enhanced detection sensitivity. The proposed contrast agents may extend the applicability of OCT to the problems that require the molecular contrast with enhanced sensitivity.

© 2011 OSA

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(110.0113) Imaging systems : Imaging through turbid media
(160.1585) Materials : Chiral media
(290.5855) Scattering : Scattering, polarization

ToC Category:
Imaging Systems

History
Original Manuscript: April 4, 2011
Revised Manuscript: May 20, 2011
Manuscript Accepted: June 2, 2011
Published: July 19, 2011

Virtual Issues
Vol. 6, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Kalpesh B. Mehta and Nanguang Chen, "Plasmonic chiral contrast agents for optical coherence tomography: numerical study," Opt. Express 19, 14903-14912 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-16-14903


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