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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 16 — Aug. 1, 2011
  • pp: 15415–15428

Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography

Simon S. Gao, Anping Xia, Tao Yuan, Patrick D. Raphael, Ryan L. Shelton, Brian E. Applegate, and John S. Oghalai  »View Author Affiliations


Optics Express, Vol. 19, Issue 16, pp. 15415-15428 (2011)
http://dx.doi.org/10.1364/OE.19.015415


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Abstract

Human hearing loss often occurs as a result of damage or malformations to the functional soft tissues within the cochlea, but these changes are not appreciable with current medical imaging modalities. We sought to determine whether optical coherence tomography (OCT) could assess the soft tissue structures relevant to hearing using mouse models. We imaged excised cochleae with an altered tectorial membrane and during normal development. The soft tissue structures and expected anatomical variations were visible using OCT, and quantitative measurements confirmed the ability to detect critical changes relevant to hearing.

© 2011 OSA

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4940) Medical optics and biotechnology : Otolaryngology

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 20, 2011
Revised Manuscript: July 13, 2011
Manuscript Accepted: July 20, 2011
Published: July 27, 2011

Virtual Issues
Vol. 6, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Simon S. Gao, Anping Xia, Tao Yuan, Patrick D. Raphael, Ryan L. Shelton, Brian E. Applegate, and John S. Oghalai, "Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography," Opt. Express 19, 15415-15428 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-16-15415


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