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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 18 — Aug. 29, 2011
  • pp: 17683–17690

Super-sensitivity in label-free protein sensing using a nanoslot nanolaser

Shota Kita, Shoji Hachuda, Shota Otsuka, Tatsuro Endo, Yasunori Imai, Yoshiaki Nishijima, Hiroaki Misawa, and Toshihiko Baba  »View Author Affiliations

Optics Express, Vol. 19, Issue 18, pp. 17683-17690 (2011)

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Microphotonic sensors have been actively studied with increasing demands for label-free biosensing in medical diagnoses and life sciences. For high-throughput and low-cost sensing, a high sensitivity is crucial for eliminating the pre-concentration process, while a simple setup of sensors is also desirable. This paper demonstrates a super-sensitivity for protein, which satisfies these requirements. The key device is a photonic crystal nanolaser, in particular with a nanoslot. Even using a simple setup, the nanolaser achieves an extraordinary-low detection limit for BSA protein, i.e. 255 fM on an average, which cannot be explained by its bulk index sensitivity. The specific adsorption of the protein is observed only around the nanoslot with strong laser intensity. This suggests that the super-sensitivity arises from the effective trapping of protein in the nanoslot.

© 2011 OSA

OCIS Codes
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(140.3945) Lasers and laser optics : Microcavities
(230.5298) Optical devices : Photonic crystals

ToC Category:

Original Manuscript: June 14, 2011
Revised Manuscript: July 25, 2011
Manuscript Accepted: August 13, 2011
Published: August 24, 2011

Virtual Issues
Vol. 6, Iss. 9 Virtual Journal for Biomedical Optics

Shota Kita, Shoji Hachuda, Shota Otsuka, Tatsuro Endo, Yasunori Imai, Yoshiaki Nishijima, Hiroaki Misawa, and Toshihiko Baba, "Super-sensitivity in label-free protein sensing using a nanoslot nanolaser," Opt. Express 19, 17683-17690 (2011)

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