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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 19 — Sep. 12, 2011
  • pp: 18636–18644

Contrast enhanced high-resolution diffuse optical tomography of the human brain using ICG

Christina Habermehl, Christoph H. Schmitz, and Jens Steinbrink  »View Author Affiliations

Optics Express, Vol. 19, Issue 19, pp. 18636-18644 (2011)

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Non-invasive diffuse optical tomography (DOT) of the adult brain has recently been shown to improve the spatial resolution for functional brain imaging applications. Here we show that high-resolution (HR) DOT is also advantageous for clinical perfusion imaging using an optical contrast agent. We present the first HR-DOT results with a continuous wave near infrared spectroscopy setup using a dense grid of optical fibers and indocyanine green (ICG) as an exogenic contrast agent. We find an early arrival of the ICG bolus in the intracerebral tissue and a delayed arrival of the bolus in the extracerebral tissue, achieving the separation of both layers. This demonstrates the method’s potential for brain perfusion monitoring in neurointensive care patients.

© 2011 OSA

OCIS Codes
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 31, 2011
Manuscript Accepted: August 31, 2011
Published: September 8, 2011

Virtual Issues
Vol. 6, Iss. 10 Virtual Journal for Biomedical Optics

Christina Habermehl, Christoph H. Schmitz, and Jens Steinbrink, "Contrast enhanced high-resolution diffuse optical tomography of the human brain using ICG," Opt. Express 19, 18636-18644 (2011)

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