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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 2 — Jan. 17, 2011
  • pp: 1271–1283

Comprehensive in vivo micro-vascular imaging of the human eye by dual-beam-scan Doppler optical coherence angiography

Shuichi Makita, Franck Jaillon, Masahiro Yamanari, Masahiro Miura, and Yoshiaki Yasuno  »View Author Affiliations


Optics Express, Vol. 19, Issue 2, pp. 1271-1283 (2011)
http://dx.doi.org/10.1364/OE.19.001271


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Abstract

Comprehensive angiography provides insight into the diagnosis of vascular-related diseases. However, complex microvascular networks of unstable in vivo organs such as the eye require micron-scale resolution in three dimensions and a high sampling rate to access a wide area as maintaining the high resolution. Here, we introduce dual-beam-scan Doppler optical coherence angiography (OCA) as a label-free comprehensive ophthalmic angiography that satisfies theses requirements. In addition to high resolution and high imaging speed, high sensitivity to motion for detecting tiny blood flow of microvessels is achieved by detecting two time-delayed signals with scanning of two probing beams separated on a sample. We present in vivo three-dimensional imaging of the microvasculature of the posterior part of the human eye. The demonstrated results show that this technique may be used for comprehensive ophthalmic angiography to evaluate the vasculature of the posterior human eye and to diagnose variety of vascular diseases.

© 2011 OSA

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 24, 2010
Revised Manuscript: January 7, 2011
Manuscript Accepted: January 9, 2011
Published: January 11, 2011

Virtual Issues
Vol. 6, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Shuichi Makita, Franck Jaillon, Masahiro Yamanari, Masahiro Miura, and Yoshiaki Yasuno, "Comprehensive in vivo micro-vascular imaging of the human eye by dual-beam-scan Doppler optical coherence angiography," Opt. Express 19, 1271-1283 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-2-1271


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