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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 2 — Jan. 17, 2011
  • pp: 1291–1300

High-throughput detection of immobilized plasmonic nanoparticles by a hyperspectral imaging system based on Fourier transform spectrometry

Te-Yu Tseng, Pau-Jen Lai, and Kung-Bin Sung  »View Author Affiliations


Optics Express, Vol. 19, Issue 2, pp. 1291-1300 (2011)
http://dx.doi.org/10.1364/OE.19.001291


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Abstract

To facilitate the application of plasmonic nanoparticles (PNPs) in high-throughput detection, we develop a hyperspectral imaging system (HSIS) combining dark-filed microscopy and imaging Fourier transform spectrometry to measure scattering spectra from immobilized PNPs. The current setup has acquisition time of 5 seconds and spectral resolution of 21.4 nm at 532.1 nm. We demonstrate the applicability of the HSIS in conjunction with spectral data analysis to quantify multiple types of PNPs and detect small changes in localized surface plasmon resonance wavelengths of PNPs due to changes in the environmental refractive index.

© 2011 OSA

OCIS Codes
(180.0180) Microscopy : Microscopy
(240.6680) Optics at surfaces : Surface plasmons
(290.5850) Scattering : Scattering, particles
(300.6300) Spectroscopy : Spectroscopy, Fourier transforms
(300.6550) Spectroscopy : Spectroscopy, visible
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Microscopy

History
Original Manuscript: November 30, 2010
Revised Manuscript: December 21, 2010
Manuscript Accepted: December 28, 2010
Published: January 11, 2011

Virtual Issues
Vol. 6, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Te-Yu Tseng, Pau-Jen Lai, and Kung-Bin Sung, "High-throughput detection of immobilized plasmonic nanoparticles by a hyperspectral imaging system based on Fourier transform spectrometry," Opt. Express 19, 1291-1300 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-2-1291


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