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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 2 — Jan. 17, 2011
  • pp: 552–561

Optics InfoBase > Optics Express > Volume 19 > Issue 2 > Page 552

Polarization-sensitive optical frequency domain imaging based on unpolarized light

Ki Hean Kim, B. Hyle Park, Yupeng Tu, Tayyaba Hasan, Byunghak Lee, Jianan Li, and Johannes F. de Boer  »View Author Affiliations


Optics Express, Vol. 19, Issue 2, pp. 552-561 (2011)
http://dx.doi.org/10.1364/OE.19.000552


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Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) is an augmented form of OCT, providing 3D images of both tissue structure and polarization properties. We developed a new method of polarization-sensitive optical frequency domain imaging (PS-OFDI), which is based on a wavelength-swept source. In this method the sample was illuminated with unpolarized light, which was composed of two orthogonal polarization states (i.e., separated by 180° in the Poincaré sphere) that are uncorrelated to each other. Reflection of these polarization states from within the sample was detected simultaneously and independently using a frequency multiplexing scheme. This simultaneous sample probing with two polarization states enabled determination of the depth-resolved Jones matrices of the sample. Polarization properties of the sample were obtained by analyzing the sample Jones matrices through eigenvector decomposition. The new PS-OFDI system ran at 31K wavelength-scans/s with 3072 pixels per wavelength-scan, and was tested by imaging a polarizer and several birefringent tissues such as chicken muscle and human skin. Lastly the new PS-OFDI was applied to imaging two cancer animal models: a mouse model by injecting cancer cells and a hamster cheek pouch model. These animal model studies demonstrated the significant differences in tissue polarization properties between cancer and normal tissues in vivo.

© 2011 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(260.1440) Physical optics : Birefringence
(260.5430) Physical optics : Polarization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 19, 2010
Revised Manuscript: December 9, 2010
Manuscript Accepted: December 16, 2010
Published: January 4, 2011

Virtual Issues
Vol. 6, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Ki Hean Kim, B. Hyle Park, Yupeng Tu, Tayyaba Hasan, Byunghak Lee, Jianan Li, and Johannes F. de Boer, "Polarization-sensitive optical frequency domain imaging based on unpolarized light," Opt. Express 19, 552-561 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-2-552


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