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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 20 — Sep. 26, 2011
  • pp: 18965–18978

Multiplex spectral surface plasmon resonance imaging (SPRI) sensor based on the polarization control scheme

Chi Lok Wong, George Chung Kit Chen, Beng Koon Ng, Shuchi Agarwal, Zhiping Lin, Peng Chen, and Ho Pui Ho  »View Author Affiliations


Optics Express, Vol. 19, Issue 20, pp. 18965-18978 (2011)
http://dx.doi.org/10.1364/OE.19.018965


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Abstract

A two-dimensional (2D) spectral SPR sensor based on a polarization control scheme is reported in this paper. The polarization control configuration converts the phase difference between p- and s- polarization occurring at surface plasmon resonance (SPR) into corresponding color responses in spectral SPR images. A sensor resolution of 2.7 x 10−6 RIU has been demonstrated, which corresponds to more than one order of magnitude resolution improvement (26 times) comparing to existing 2D spectral SPR sensors. Multiplex array detection has also been demonstrated with the spectral SPR imaging sensor. In a 8 x 4 sensor array, 32 samples with different refractive index values were monitored simultaneously. Detection on bovine serum albumin (BSA) antigen-antibody binding further demonstrated the multiplex detection capability of the 2D spectral SPR sensor for bio-molecular interactions. The detection limit is found to be 21ng/ml, which is 36 times better than the detection limit previously reported by phase imaging SPR sensors. In light of the advantages of high sensitivity, 2D multiplex detection and real-time response, the spectral SPR imaging sensor can find promising applications in rapid, high throughput, non-labeling and multiplex detection of protein array for proteomics studies, biomarker screening, disease prognosis, and drug discovery.

© 2011 OSA

OCIS Codes
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(240.6680) Optics at surfaces : Surface plasmons
(260.5430) Physical optics : Polarization
(300.6490) Spectroscopy : Spectroscopy, surface
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:
Sensors

History
Original Manuscript: March 24, 2011
Revised Manuscript: April 25, 2011
Manuscript Accepted: April 25, 2011
Published: September 15, 2011

Virtual Issues
Vol. 6, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Chi Lok Wong, George Chung Kit Chen, Beng Koon Ng, Shuchi Agarwal, Zhiping Lin, Peng Chen, and Ho Pui Ho, "Multiplex spectral surface plasmon resonance imaging (SPRI) sensor based on the polarization control scheme," Opt. Express 19, 18965-18978 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-20-18965


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