OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 20 — Sep. 26, 2011
  • pp: 19480–19485

Structured three-dimensional optical phantom for optical coherence tomography

Andrea Curatolo, Brendan F. Kennedy, and David D. Sampson  »View Author Affiliations


Optics Express, Vol. 19, Issue 20, pp. 19480-19485 (2011)
http://dx.doi.org/10.1364/OE.19.019480


View Full Text Article

Enhanced HTML    Acrobat PDF (856 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We present a three-dimensional structured tissue-mimicking phantom for use in optical coherence tomography (OCT). The phantom was fabricated from a silicone matrix and titanium dioxide additive using a lithographic casting method capable of producing a wide range of well-defined geometries with optical contrast and mesoscopic feature sizes relevant to OCT. We describe the fabrication, characterization and OCT imaging of two phantoms and demonstrate their utility in assessing the performance of a spatial-diversity speckle reduction technique. Such phantoms will be important in the development of standards in OCT, as well as in enabling quantitative performance assessment.

© 2011 OSA

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(110.4500) Imaging systems : Optical coherence tomography
(110.5220) Imaging systems : Photolithography
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Imaging Systems

History
Original Manuscript: July 1, 2011
Revised Manuscript: August 22, 2011
Manuscript Accepted: September 2, 2011
Published: September 22, 2011

Virtual Issues
Vol. 6, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Andrea Curatolo, Brendan F. Kennedy, and David D. Sampson, "Structured three-dimensional optical phantom for optical coherence tomography," Opt. Express 19, 19480-19485 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-20-19480


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. B. W. Pogue and M. S. Patterson, “Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry,” J. Biomed. Opt.11(4), 041102 (2006). [CrossRef] [PubMed]
  2. C. E. Bisaillon, G. Lamouche, R. Maciejko, M. Dufour, and J. P. Monchalin, “Deformable and durable phantoms with controlled density of scatterers,” Phys. Med. Biol.53(13), N237–N247 (2008). [CrossRef] [PubMed]
  3. C. U. Devi, R. M. Vasu, and A. K. Sood, “Design, fabrication, and characterization of a tissue-equivalent phantom for optical elastography,” J. Biomed. Opt.10(4), 44020 (2005). [CrossRef] [PubMed]
  4. B. F. Kennedy, S. Loitsch, R. A. McLaughlin, L. Scolaro, P. Rigby, and D. D. Sampson, “Fibrin phantom for use in optical coherence tomography,” J. Biomed. Opt.15(3), 030507 (2010). [CrossRef] [PubMed]
  5. B. F. Kennedy, T. R. Hillman, A. Curatolo, and D. D. Sampson, “Speckle reduction in optical coherence tomography by strain compounding,” Opt. Lett.35(14), 2445–2447 (2010). [CrossRef] [PubMed]
  6. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991). [CrossRef] [PubMed]
  7. D. M. de Bruin, R. H. Bremmer, V. M. Kodach, R. de Kinkelder, J. van Marle, T. G. van Leeuwen, and D. J. Faber, “Optical phantoms of varying geometry based on thin building blocks with controlled optical properties,” J. Biomed. Opt.15(2), 025001 (2010). [CrossRef] [PubMed]
  8. J. M. Schmitt, S. H. Xiang, and K. M. Yung, “Speckle in optical coherence tomography,” J. Biomed. Opt.4(1), 95–105 (1999). [CrossRef]
  9. D. P. Popescu, M. D. Hewko, and M. G. Sowa, “Speckle noise attenuation in optical coherence tomography by compounding images acquired at different positions of the sample,” Opt. Commun.269(1), 247–251 (2007). [CrossRef]
  10. Y. Xia and G. M. Whitesides, “Soft lithography,” Angew. Chem. Int. Ed.37(5), 550–575 (1998). [CrossRef]
  11. A. E. Desjardins, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Speckle reduction in OCT using massively-parallel detection and frequency-domain ranging,” Opt. Express14(11), 4736–4745 (2006). [CrossRef] [PubMed]
  12. T. Moffitt, Y. C. Chen, and S. A. Prahl, “Preparation and characterization of polyurethane optical phantoms,” J. Biomed. Opt.11(4), 041103 (2006). [CrossRef] [PubMed]
  13. P. D. Woolliams, R. A. Ferguson, C. Hart, A. Grimwood, and P. H. Tomlins, “Spatially deconvolved optical coherence tomography,” Appl. Opt.49(11), 2014–2021 (2010). [CrossRef] [PubMed]
  14. A. Agrawal, T. J. Pfefer, N. Gilani, and R. Drezek, “Three-dimensional characterization of optical coherence tomography point spread functions with a nanoparticle-embedded phantom,” Opt. Lett.35(13), 2269–2271 (2010). [CrossRef] [PubMed]
  15. P. D. Woolliams and P. H. Tomlins, “Estimating the resolution of a commercial optical coherence tomography system with limited spatial sampling,” Meas. Sci. Technol.22(6), 065502 (2011). [CrossRef]
  16. P. H. Tomlins, G. N. Smith, P. D. Woolliams, J. Rasakanthan, and K. Sugden, “Femtosecond laser micro-inscription of optical coherence tomography resolution test artifacts,” Biomed. Opt. Express2(5), 1319–1327 (2011). [CrossRef] [PubMed]
  17. R. J. Nordstrom, “Phantoms as standards in optical measurements,” Proc. SPIE7906, 79060H–5,(2011). [CrossRef]
  18. T. R. Hillman, A. Curatolo, B. F. Kennedy, and D. D. Sampson, “Detection of multiple scattering in optical coherence tomography by speckle correlation of angle-dependent B-scans,” Opt. Lett.35(12), 1998–2000 (2010). [CrossRef] [PubMed]
  19. B. F. Kennedy, X. Liang, S. G. Adie, D. K. Gerstmann, B. C. Quirk, S. A. Boppart, and D. D. Sampson, “In vivo three-dimensional optical coherence elastography,” Opt. Express19(7), 6623–6634 (2011). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 

Multimedia

Multimedia FilesRecommended Software
» Media 1: MOV (3658 KB)      QuickTime

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited