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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 20 — Sep. 26, 2011
  • pp: 19523–19531

Performance of THz fiber-scanning near-field microscopy to diagnose breast tumors

Hua Chen, Wen-Jeng Lee, Hsin-Yi Huang, Chui-Min Chiu, Yuan-Fu Tsai, Tzu-Fang Tseng, Jen-Tang Lu, Wei-Ling Lai, and Chi-Kuang Sun  »View Author Affiliations


Optics Express, Vol. 19, Issue 20, pp. 19523-19531 (2011)
http://dx.doi.org/10.1364/OE.19.019523


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Abstract

Based on tissues from 20 female patients (mean age: 53 years; rang: 36-72 years), we examine the performance of a room-temperature-operated terahertz (THz) fiber-scanning near-field microscopy to diagnose slices of breast tissues. The specimens were frozen sliced and then measured in a thawed state without dehydration. We performed the imaging at 320GHz. Our study indicates that images acquired in the THz transmission-illumination mode can all clearly distinguish breast tumor tissues from normal tissues without H&E staining. Due to its capability to perform quantitative analysis and to allow follow-up staining and traditional pathohistological analysis, our study indicates great potential of the THz fiber-scanning near-field microscopy for future automation, which is critical for fast and complete pre-screening on breast tumor pathological examinations and for assisting quick definition of the tumor margins during the surgical procedure such as breast-conserving surgery.

© 2011 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.6795) Imaging systems : Terahertz imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 20, 2011
Revised Manuscript: August 31, 2011
Manuscript Accepted: August 31, 2011
Published: September 22, 2011

Virtual Issues
Vol. 6, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Hua Chen, Wen-Jeng Lee, Hsin-Yi Huang, Chui-Min Chiu, Yuan-Fu Tsai, Tzu-Fang Tseng, Jen-Tang Lu, Wei-Ling Lai, and Chi-Kuang Sun, "Performance of THz fiber-scanning near-field microscopy to diagnose breast tumors," Opt. Express 19, 19523-19531 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-20-19523


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