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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 20 — Sep. 26, 2011
  • pp: 19781–19789

Quantitative single-exposure x-ray phase contrast imaging using a single attenuation grid

Kaye S. Morgan, David M. Paganin, and Karen K. W. Siu  »View Author Affiliations


Optics Express, Vol. 19, Issue 20, pp. 19781-19789 (2011)
http://dx.doi.org/10.1364/OE.19.019781


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Abstract

A single-exposure quantitative method of x-ray phase contrast imaging, suitable for animal in vivo observations, is described and shown experimentally both for a known static sample and an ex vivo biological airway. The ability to acquire the desired information within a single exposure is important for dynamic samples, as is sufficient sensitivity to reveal small variations in the composition or thickness of such a sample. This approach satisfies both these needs by analyzing how a reference grid pattern is deformed by the presence of the sample, similar to a Shack-Hartmann sensor. By resolving the shift of the pattern into horizontal and vertical components, a quantitative phase depth map is recovered, sensitive to both sharp edges as well as low phase gradients.

© 2011 OSA

OCIS Codes
(050.5080) Diffraction and gratings : Phase shift
(110.7440) Imaging systems : X-ray imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(260.0260) Physical optics : Physical optics
(340.0340) X-ray optics : X-ray optics
(340.7440) X-ray optics : X-ray imaging

ToC Category:
X-ray Optics

History
Original Manuscript: August 8, 2011
Revised Manuscript: September 12, 2011
Manuscript Accepted: September 13, 2011
Published: September 23, 2011

Virtual Issues
Vol. 6, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Kaye S. Morgan, David M. Paganin, and Karen K. W. Siu, "Quantitative single-exposure x-ray phase contrast imaging using a single attenuation grid," Opt. Express 19, 19781-19789 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-20-19781


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References

  1. A. Snigirev, I. Snigireva, V. Kohn, S. Kuznetsov, and I. Schelokov, “On the possibilities of x-ray phase contrast microimaging by coherent high-energy synchrotron radiation,” Rev. Sci. Instrum.66(12), 5486–5492 (1995). [CrossRef]
  2. P. Cloetens, R. Barrett, J. Baruchel, J. P. Guigay, and M. Schlenker, “Phase objects in synchrotron radiation hard x-ray imaging,” J. Phys. D Appl. Phys.29(1), 133–146 (1996). [CrossRef]
  3. R. A. Lewis, “Medical phase contrast x-ray imaging: current status and future prospects,” Phys. Med. Biol.49(16), 3573–3583 (2004). [CrossRef] [PubMed]
  4. T. E. Gureyev, S. C. Mayo, D. E. Myers, Ya. Nesterets, D. M. Paganin, A. Pogany, A. W. Stevenson, and S. W. Wilkins, “Refracting Röntgen’s rays: Propagation-based x-ray phase contrast for biomedical imaging,” J. Appl. Phys.105(10), 102005 (2009). [CrossRef]
  5. A. Fouras, M. J. Kitchen, S. Dubsky, R. A. Lewis, S. B. Hooper, and K. Hourigan, “The past, present, and future of x-ray technology for in vivo imaging of function and form,” J. Appl. Phys.105(10), 102009 (2009). [CrossRef]
  6. U. Bonse and M. Hart, “An x-ray interferometer,” Appl. Phys. Lett.6(8), 155–156 (1965). [CrossRef]
  7. E. Förster, K. Goetz, and P. Zaumseil, “Double crystal diffractometry for the characterization of targets for laser fusion experiments,” Krist. Tech.15(8), 937–945 (1980). [CrossRef]
  8. V. Ingal and E. Beliaevskaya, “X-ray plane-wave topography observation of the phase contrast from a non-crystalline object,” J. Phys. D Appl. Phys.28(11), 2314–2317 (1995). [CrossRef]
  9. T. J. Davis, D. Gao, T. E. Gureyev, A. W. Stevenson, and S. W. Wilkins, “Phase-contrast imaging of weakly absorbing materials using hard x-rays,” Nature373(6515), 595–598 (1995). [CrossRef]
  10. C. David, B. Nohammer, H. Solak, and E. Ziegler, “Differential x-ray phase contrast imaging using a shearing interferometer,” Appl. Phys. Lett.81(17), 3287–3289 (2002). [CrossRef]
  11. A. Momose, W. Yashiro, Y. Takeda, Y. Suzuki, and T. Hattori, “Phase tomography by x-ray Talbot interferometry for biological imaging,” Jpn. J. Appl. Phys.45(6A), 5254–5262 (2006). [CrossRef]
  12. F. Pfeiffer, T. Weitkamp, O. Bunk, and C. David, “Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources,” Nat. Phys.2(4), 258–261 (2006). [CrossRef]
  13. D. Paganin, T. E. Gureyev, K. M. Pavlov, R. A. Lewis, and M. Kitchen, “Phase retrieval using coherent imaging systems with linear transfer functions,” Opt. Commun.234(1-6), 87–105 (2004). [CrossRef]
  14. D. Briedis, K. K. W. Siu, D. M. Paganin, K. M. Pavlov, and R. A. Lewis, “Analyser-based mammography using single-image reconstruction,” Phys. Med. Biol.50(15), 3599–3611 (2005). [CrossRef] [PubMed]
  15. K. K. W. Siu, M. J. Kitchen, K. M. Pavlov, J. E. Gillam, R. A. Lewis, K. Uesugi, and N. Yagi, “An improvement to the diffraction-enhanced imaging method that permits imaging of dynamical systems,” Nucl. Instrum. Methods Phys. Res. A548(1-2), 169–174 (2005). [CrossRef]
  16. M. J. Kitchen, K. M. Pavlov, S. B. Hooper, D. J. Vine, K. K. W. Siu, M. J. Wallace, M. L. L. Siew, N. Yagi, K. Uesugi, and R. A. Lewis, “Simultaneous acquisition of dual analyzer-based phase contrast x-ray images for small animal imaging,” Eur. J. Radiol.68(3), S49–S53 (2008). [CrossRef] [PubMed]
  17. K. S. Morgan, D. M. Paganin, and K. K. W. Siu, “Quantitative x-ray phase-contrast imaging using a single grating of comparable pitch to sample feature size,” Opt. Lett.36(1), 55–57 (2011). [CrossRef] [PubMed]
  18. M. R. Arnison, K. G. Larkin, C. J. R. Sheppard, N. I. Smith, and C. J. Cogswell, “Linear phase imaging using differential interference contrast microscopy,” J. Microsc.214(1), 7–12 (2004). [CrossRef] [PubMed]
  19. C. Kottler, C. David, F. Pfeiffer, and O. Bunk, “A two-directional approach for grating based differential phase contrast imaging using hard x-rays,” Opt. Express15(3), 1175–1181 (2007). [CrossRef] [PubMed]
  20. M. D. de Jonge, B. Hornberger, C. Holzner, D. Legnini, D. Paterson, I. McNulty, C. Jacobsen, and S. Vogt, “Quantitative phase imaging with a scanning transmission x-ray microscope,” Phys. Rev. Lett.100(16), 163902 (2008). [CrossRef] [PubMed]
  21. J. Hartmann, “Bemerkungen über den Bau und die Justirung von Spektrographen,” Z. Instrumentenkd20, 47 (1900).
  22. R. V. Shack and B. C. Platt, “Production and use of a lenticular Hartmann screen,” J. Opt. Soc. Am.61, 656 (1971).
  23. V. Aksenov, V. Banakh, and O. Tikhomirova, “Potential and vortex features of optical speckle fields and visualization of wave-front singularities,” Appl. Opt.37(21), 4536–4540 (1998). [CrossRef] [PubMed]
  24. R. G. Lane and M. Tallon, “Wave-front reconstruction using a Shack-Hartmann sensor,” Appl. Opt.31(32), 6902–6908 (1992). [CrossRef] [PubMed]
  25. Y. Carmon and E. N. Ribak, “Phase retrieval by demodulation of a Hartmann-Shack sensor,” Opt. Commun.215(4-6), 285–288 (2003). [CrossRef]
  26. S. C. Mayo and B. Sexton, “Refractive microlens array for wave-front analysis in the medium to hard x-ray range,” Opt. Lett.29(8), 866–868 (2004). [CrossRef] [PubMed]
  27. P. Mercère, M. Idir, P. Zeitoun, X. Levecq, G. Dovillaire, S. Bucourt, D. Douillet, K. A. Goldberg, P. P. Naulleau, and S. Rekawa, “X-ray wavefront Hartmann Sensor,” AIP Conf. Proc.705, 819–822 (2004). [CrossRef]
  28. C. D. Perciante and J. A. Ferrari, “Visualization of two-dimensional phase gradients by subtraction of a reference periodic pattern,” Appl. Opt.39(13), 2081–2083 (2000). [CrossRef] [PubMed]
  29. M. Takeda, H. Ina, and S. Kobayashi, “Fourier-transform method of fringe-pattern analysis for computer-based tomography and interferometry,” J. Opt. Soc. Am. A72(1), 156–160 (1982). [CrossRef]
  30. J. H. Massig, “Measurement of phase objects by simple means,” Appl. Opt.38(19), 4103–4105 (1999). [CrossRef] [PubMed]
  31. J. H. Massig, “Deformation measurement on specular surfaces by simple means,” Opt. Eng.40(10), 2315–2318 (2001). [CrossRef]
  32. P. Bon, G. Maucort, B. Wattellier, and S. Monneret, “Quadriwave lateral shearing interferometry for quantitative phase microscopy of living cells,” Opt. Express17(15), 13080–13094 (2009). [CrossRef] [PubMed]
  33. H. H. Wen, E. E. Bennett, R. Kopace, A. F. Stein, and V. Pai, “Single-shot x-ray differential phase-contrast and diffraction imaging using two-dimensional transmission gratings,” Opt. Lett.35(12), 1932–1934 (2010). [CrossRef] [PubMed]
  34. H. Itoh, K. Nagai, G. Sato, K. Yamaguchi, T. Nakamura, T. Kondoh, C. Ouchi, T. Teshima, Y. Setomoto, and T. Den, “Two-dimensional grating-based X-ray phase-contrast imaging using Fourier transform phase retrieval,” Opt. Express19(4), 3339–3346 (2011). [CrossRef] [PubMed]
  35. Y. Liu, B. Chen, E. Li, J. Wang, A. Marcelli, S. Wilkins, H. Ming, Y. Tian, K. Nugent, P. Zhu, and Z. Wu, “Phase retrieval in x-ray imaging based on using structured illumination,” Phys. Rev. A78(2), 023817 (2008). [CrossRef]
  36. D. N. Slatkin, P. Spanne, F. A. Dilmanian, and M. Sandborg, “Microbeam radiation therapy,” Med. Phys.19(6), 1395–1400 (1992). [CrossRef] [PubMed]
  37. J. P. Lewis, “Fast template matching”, Vision Interface 95, Canadian Image Processing and Pattern Recognition Society, Quebec City, 120–123 (1995).
  38. D. M. Paganin, Coherent X-ray Optics, Oxford University Press, New York (2006).
  39. C. T. Chantler, K. Olsen, R. A. Dragoset, A. R. Kishore, S. A. Kotochigova, and D. S. Zucker, “X-ray form factor, attenuation and scattering tables”, http://www.nist.gov/pml/data/ffast/index.cfm , NIST (2003).
  40. D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, and K. K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat.213(2), 217–227 (2008). [CrossRef] [PubMed]
  41. K. K. W. Siu, K. S. Morgan, D. M. Paganin, R. Boucher, K. Uesugi, N. Yagi, and D. W. Parsons, “Phase contrast X-ray imaging for the non-invasive detection of airway surfaces and lumen characteristics in mouse models of airway disease,” Eur. J. Radiol.68(3Suppl), S22–S26 (2008). [CrossRef] [PubMed]
  42. M. Donnelley, K. K. W. Siu, K. S. Morgan, W. Skinner, Y. Suzuki, A. Takeuchi, K. Uesugi, N. Yagi, and D. W. Parsons, “A new technique to examine individual pollutant particle and fibre deposition and transit behaviour in live mouse trachea,” J. Synchrotron Radiat.17(6), 719–729 (2010). [CrossRef] [PubMed]
  43. K. S. Morgan, D. M. Paganin, D. W. Parsons, M. Donnelley, N. Yagi, K. Uesugi, Y. Suzuki, A. Takeuchi, and K. K. W. Siu, “Optimising coherence properties for phase contrast x-ray imaging (PCXI) to reveal airway surface liquid (ASL) as an airway health measure,” IFMBE Proc.25, 135–138 (2009). [CrossRef]
  44. A. M. Lale, J. D. T. Mason, and N. S. Jones, “Mucociliary transport and its assessment: a review,” Clin. Otolaryngol. Allied Sci.23(5), 388–396 (1998). [CrossRef] [PubMed]
  45. M. R. Teague, “Deterministic phase retrieval: a Green’s function solution,” J. Opt. Soc. Am.73(11), 1434–1441 (1983). [CrossRef]
  46. D. Paganin, S. C. Mayo, T. E. Gureyev, P. R. Miller, and S. W. Wilkins, “Simultaneous phase and amplitude extraction from a single defocused image of a homogenous object,” J. Microsc.206(1), 33–40 (2002). [CrossRef] [PubMed]
  47. K. S. Morgan, S. C. Irvine, Y. Suzuki, K. Uesugi, A. Takeuchi, D. M. Paganin, and K. K. W. Siu, “Measurement of hard x-ray coherence in the presence of a rotating random-phase-screen diffuser,” Opt. Commun.283(2), 216–225 (2010). [CrossRef]
  48. S. C. Irvine, K. S. Morgan, Y. Suzuki, K. Uesugi, A. Takeuchi, D. M. Paganin, and K. K. W. Siu, “Assessment of the use of a diffuser in propagation-based x-ray phase contrast imaging,” Opt. Express18(13), 13478–13491 (2010). [CrossRef] [PubMed]

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