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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 21 — Oct. 10, 2011
  • pp: 20097–20102

Real-time handheld optical-resolution photoacoustic microscopy

Parsin Hajireza, Wei Shi, and Roger J. Zemp  »View Author Affiliations

Optics Express, Vol. 19, Issue 21, pp. 20097-20102 (2011)

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In this paper a new generation of optical-resolution photoacoustic microscopy (OR-PAM) with a wide range of potential clinical applications is demonstrated. Using fast scanning mirrors, an image guide with 30,000 fiber pixels, a refocusing lens and a unique probe we managed to reduce the footprint of an OR-PAM system from a stationary table-top system to a portable, 4cm by 6cm, probe weighing ~500g tethered to a scanning unit. The phantom studies show that the handheld optical-resolution photoacoustic microscope is able to image with ~7μm resolution. For in vivo studies images of the microvasculature in a Swiss Webster mouse ear are shown. The compact, flexible nature of the proposed design and the small footprint of the apparatus increase the usability of OR-PAM for potential clinical applications such as in dermatology.

© 2011 OSA

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(180.5810) Microscopy : Scanning microscopy
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 25, 2011
Revised Manuscript: September 9, 2011
Manuscript Accepted: September 9, 2011
Published: September 29, 2011

Virtual Issues
Vol. 6, Iss. 11 Virtual Journal for Biomedical Optics

Parsin Hajireza, Wei Shi, and Roger J. Zemp, "Real-time handheld optical-resolution photoacoustic microscopy," Opt. Express 19, 20097-20102 (2011)

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  1. W. Shi, P. Hajireza, P. Shao, S. Kerr, and R. J. Zemp, “Real-time optical-resolution photoacoustic microscopy using fiber-laser technology,” Proc. SPIE 7899, 789939, 789939-6 (2011). [CrossRef]
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