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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 23 — Nov. 7, 2011
  • pp: 22837–22850

Ultrasound modulated optical tomography: Young’s modulus of the insonified region from measurement of natural frequency of vibration

R. Sriram Chandran, Debasish Roy, Rajan Kanhirodan, Ram Mohan Vasu, and C. Usha Devi  »View Author Affiliations


Optics Express, Vol. 19, Issue 23, pp. 22837-22850 (2011)
http://dx.doi.org/10.1364/OE.19.022837


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Abstract

We demonstrate a method to recover the Young’s modulus (E) of a tissue-mimicking phantom from measurements of ultrasound modulated optical tomography (UMOT). The object is insonified by a dual-beam, confocal ultrasound transducer (US) oscillating at frequencies f0 and f0 + Δf and the variation of modulation depth (M) in the autocorrelation of light traversed through the focal region of the US transducer against Δf is measured. From the dominant peaks observed in the above variation, the natural frequencies of the insonified region associated with the vibration along the US transducer axis are deduced. A consequence of the above resonance is that the speckle fluctuation at the resonance frequency has a higher signal-to-noise to ratio (SNR). From these natural frequencies and the associated eigenspectrum of the oscillating object, Young’s modulus (E) of the material in the focal region is recovered. The working of this method is confirmed by recovering E in the case of three tissue-mimicking phantoms of different elastic modulus values.

© 2011 OSA

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(110.6150) Imaging systems : Speckle imaging
(110.7170) Imaging systems : Ultrasound
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

Virtual Issues
Vol. 7, Iss. 1 Virtual Journal for Biomedical Optics

Citation
R. Sriram Chandran, Debasish Roy, Rajan Kanhirodan, Ram Mohan Vasu, and C. Usha Devi, "Ultrasound modulated optical tomography: Young’s modulus of the insonified region from measurement of natural frequency of vibration," Opt. Express 19, 22837-22850 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-23-22837


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